It has been extensively studied (it's been around for 36 years), and there's no reason to believe anything will happen to you whatsoever. Keep in mind that you

It has been extensively studied (it's been around for 36 years), and there's no reason to believe anything will happen to you whatsoever. Keep in mind that you only eat one six hundredth as much as you would sugar. Conversely, imagine if sugar were a newly discovered sweetening compound, seeking FDA approval. They wouldn't get past one safety trial before "serious concerns about long term effects" knocked it out of the running. Analyzing the relative risks of sugar and sucralose, there is just no case to be made for sugar being the safer bet.