5 ms·

no GLP-1 generics until 2030 lots of people will miss out on benefits, like oh preventing death our drug system is weird

by ck2 1y ago

kube-system 1y ago
Compounded GLP-1s are still floating around in the US
- ck2 1y ago
  if you saw the 60 Minutes on compounding pharmacies, which are completely unregulated and never inspected, and sometimes contaminate products out of lack of care/repercussions you'd never touch a compounded pharmacy product ever again people have died from contamination
  - kube-system 11mo ago
    Compounding pharmacies are regulated by section 503 of the FD&C act, and also subject to inspection. Are you referring to the fact that the FDA does not inspect all facilities because they have limited resources? This applies to pharmaceutical companies as much as it does to compounders. If you think the FDA posts inspectors at every pharmaceutical company in India, you’d be wrong.
  - ACCount37 11mo ago
    People are straight up buying black market "research use only, not to be used in humans" GLP-1. Compounding pharmacies are reliable, safe and well regulated compared to that. Clearly, there's an entire spectrum of tradeoffs between safety/shadiness, availability and price. I think that's a good thing.
- kshahkshah 11mo ago
  I compound tirz with glycine and B12. I honestly think these are miracle drugs. I’ve never been extremely overweight but I hit a point where I had 30 pounds to lose, despite my height, and I can’t deal with the hunger amidst all my other life stresses.
  - crowbahr 11mo ago
    In a similar boat (overweight, borderline obese - slightly elevated cholesterol - high stress) and my doc has recommended I look into GLP-1s and maybe ask my insurance which types they do and don't cover. Worst comes to worst I could go compounding for about $200/mo from what I've seen.
exabrial 1y ago
Private people invested a lot of money to develop this and get it through testing. Allowing them to reap the benefits from their investment for a limited time is just fine. It's not people couldn't also: Diet, exercise, choose veggies, eat more fiber, etc
- isoprophlex 1y ago
  "Sorry bro gonna let you die because, muh investments, you see" Your closing remark is overly simplistic and offers a contradiction: if those things would work for these obese people, they wouldn't need GLPs.
  - exabrial 1y ago
    The laws of thermodynamics apply to everyone equally.
    - asdff 1y ago
      Where in thermodynamic principles does it suggest money ought to flow into the pockets of the few?
    - phantasmish 1y ago
      The standard for medical interventions usually isn’t “could it work?” or “should it work?” but “does it work?” This is why the efficacy of every single contraceptive method isn’t way higher than it is. Lots of them should work almost perfectly… but the harder they are to use correctly, the less effective they in-fact are.
      - exabrial 1y ago
        Eating less, exercising more, has worked for the entire existence of human race. In fact, it worked for me just fine too. GLP-1s are a safe and proven tool and should be used wherever appropriate to assist people. Both of these are simple facts that aren't in contradiction with either other. But saying the patent owners shouldn't be allowed to reap the benefits of their investment is ridiculous, especially when it's completely possible to lose weight in other ways. 6 years isn't that long to wait anyway.
mrtesthah 1y ago
In theory you could supplement with L-tryptophan which is metabolized into indole which then raises GLP-1 production within enteroendocrine cells. https://www.sciencedirect.com/science/article/pii/S2211124714009012 https://www.sciencedirect.com/science/article/pii/S221112471...
- matthewdgreen 1y ago
  Or anything that boosts Akkermanskia.
- Bender 1y ago
  I use that to help me stay asleep. I also feed large amounts of it to horses and deer before, during and after 4th of July since everyone here launches mortars from their fields. Helps them chill.
- degamad 1y ago
  It's not obvious that there is a benefit here - the third sentence of the summary at the top says: > Indole increased GLP-1 release during short exposures, but it reduced secretion over longer periods.
pretzellogician 11mo ago
There are already GLP-1 generics available like liraglutide; they're just not as effective as the newer ones. (This refers to the U.S. Some other countries have more generics available.)
glp1guide 11mo ago
Like others have mentioned, liraglutide already exists as a generic! It's not as good as Semaglutide or Tirzepatide, but. Also, a lot of people are still getting compounded GLP1, to the chagrin of Eli Lilly and Novo Nordisk. Separately, 2026 is about to completely change the pricing of this stuff, not even taking into account the Trump administration's recent efforts. The price of injected GLP1 is going to implode due to patents lapsing in Canada and other places -- and for the pill forms that come out soon it looks like the Trump administration is keen on keeping prices for that low as well.

no GLP-1 generics until 2030 lots of people will miss out on benefits, like oh preventing death our drug system is weird

by ck2 1y ago

no GLP-1 generics until 2030 lots of people will miss out on benefits, like oh preventing death our drug system is weird

kube-system 1y ago

Compounded GLP-1s are still floating around in the US

ck2 1y ago
if you saw the 60 Minutes on compounding pharmacies, which are completely unregulated and never inspected, and sometimes contaminate products out of lack of care/repercussions you'd never touch a compounded pharmacy product ever again people have died from contamination
- kube-system 11mo ago
  Compounding pharmacies are regulated by section 503 of the FD&C act, and also subject to inspection. Are you referring to the fact that the FDA does not inspect all facilities because they have limited resources? This applies to pharmaceutical companies as much as it does to compounders. If you think the FDA posts inspectors at every pharmaceutical company in India, you’d be wrong.
- ACCount37 11mo ago
  People are straight up buying black market "research use only, not to be used in humans" GLP-1. Compounding pharmacies are reliable, safe and well regulated compared to that. Clearly, there's an entire spectrum of tradeoffs between safety/shadiness, availability and price. I think that's a good thing.
kshahkshah 11mo ago
I compound tirz with glycine and B12. I honestly think these are miracle drugs. I’ve never been extremely overweight but I hit a point where I had 30 pounds to lose, despite my height, and I can’t deal with the hunger amidst all my other life stresses.
- crowbahr 11mo ago
  In a similar boat (overweight, borderline obese - slightly elevated cholesterol - high stress) and my doc has recommended I look into GLP-1s and maybe ask my insurance which types they do and don't cover. Worst comes to worst I could go compounding for about $200/mo from what I've seen.

exabrial 1y ago

Private people invested a lot of money to develop this and get it through testing. Allowing them to reap the benefits from their investment for a limited time is just fine. It's not people couldn't also: Diet, exercise, choose veggies, eat more fiber, etc

isoprophlex 1y ago
"Sorry bro gonna let you die because, muh investments, you see" Your closing remark is overly simplistic and offers a contradiction: if those things would work for these obese people, they wouldn't need GLPs.
- exabrial 1y ago
  The laws of thermodynamics apply to everyone equally.
  - asdff 1y ago
    Where in thermodynamic principles does it suggest money ought to flow into the pockets of the few?
  - phantasmish 1y ago
    The standard for medical interventions usually isn’t “could it work?” or “should it work?” but “does it work?” This is why the efficacy of every single contraceptive method isn’t way higher than it is. Lots of them should work almost perfectly… but the harder they are to use correctly, the less effective they in-fact are.
    - exabrial 1y ago
      Eating less, exercising more, has worked for the entire existence of human race. In fact, it worked for me just fine too. GLP-1s are a safe and proven tool and should be used wherever appropriate to assist people. Both of these are simple facts that aren't in contradiction with either other. But saying the patent owners shouldn't be allowed to reap the benefits of their investment is ridiculous, especially when it's completely possible to lose weight in other ways. 6 years isn't that long to wait anyway.

mrtesthah 1y ago

In theory you could supplement with L-tryptophan which is metabolized into indole which then raises GLP-1 production within enteroendocrine cells. https://www.sciencedirect.com/science/article/pii/S2211124714009012 https://www.sciencedirect.com/science/article/pii/S221112471...

matthewdgreen 1y ago
Or anything that boosts Akkermanskia.
Bender 1y ago
I use that to help me stay asleep. I also feed large amounts of it to horses and deer before, during and after 4th of July since everyone here launches mortars from their fields. Helps them chill.
degamad 1y ago
It's not obvious that there is a benefit here - the third sentence of the summary at the top says: > Indole increased GLP-1 release during short exposures, but it reduced secretion over longer periods.

pretzellogician 11mo ago

There are already GLP-1 generics available like liraglutide; they're just not as effective as the newer ones. (This refers to the U.S. Some other countries have more generics available.)

glp1guide 11mo ago

Like others have mentioned, liraglutide already exists as a generic! It's not as good as Semaglutide or Tirzepatide, but. Also, a lot of people are still getting compounded GLP1, to the chagrin of Eli Lilly and Novo Nordisk. Separately, 2026 is about to completely change the pricing of this stuff, not even taking into account the Trump administration's recent efforts. The price of injected GLP1 is going to implode due to patents lapsing in Canada and other places -- and for the pill forms that come out soon it looks like the Trump administration is keen on keeping prices for that low as well.