For the usual sensor stuff I stick to classic LoRaWAN. For "complex" protocols I prefer the TLV style. Biggest trick is incorporate deep-sleep as much as poss

For the usual sensor stuff I stick to classic LoRaWAN. For "complex" protocols I prefer the TLV style. Biggest trick is incorporate deep-sleep as much as possible and "waking up by interrupts". That has a big impact on your software designs.