4 ms·
The one consolation is that these efforts in vanity are unlikely to have broader impacts. Selecting embryos to avoid a known deleterious allele/gene is easily
by pcrh 11mo ago
The one consolation is that these efforts in vanity are unlikely to have broader impacts.
Selecting embryos to avoid a known deleterious allele/gene is easily done, and without any harm. Similarly, one can choose blonde hair or blue eyes, etc. However, this is less reliable as too many different genes contribute to these traits, e.g. approximately 16 genes are involved in eye color alone.
Consider an attempt to select 5 different genes each simply available in a "good" or "bad" form in both the parents, and which are randomly contributed to an embryo. Statistically, you would need to screen 97 embryos to get one single embryo that has the optimal combination.
IVF typically transplants 2 or 3 embryos per cycle, so you need 200-300 embryos to get your chosen combination of only 5 genes. A typical woman will produce 3-400 eggs in her lifetime.
So, optimal genetic selection of embryos will not be a major thing any time soon. Those paying for it are deluded.
CRISPR editing of embryos is even more complex and less likely to succeed that the simple screening of embryos described above.
If you want to optimize the genetics of offspring, it's far, far, easier to choose the parents than to engineer the embryos.