Yes. Presently, with ublock origin on fairly default settings, YouTube causes an unresponsive tab that doesn't play the video, and a blast of errors on the cons

Yes. Presently, with ublock origin on fairly default settings, YouTube causes an unresponsive tab that doesn't play the video, and a blast of errors on the console. Disabling UBO on youtube.com fixed the problem instantly for me (which is fine since I pay for YouTube Premium because it's the correct solution to the problem of "pay content creators and don't destroy my experience")