>First-generation antihistamines include medications such as diphenhydramine (Benadryl), brompheniramine, doxylamine, chlorpheniramine, hydroxyzine, and prometh

>First-generation antihistamines include medications such as diphenhydramine (Benadryl), brompheniramine, doxylamine, chlorpheniramine, hydroxyzine, and promethazine. >First-generation antihistamines have a longer onset and shorter duration of action with less efficacy than second-generation antihistamines, such as cetirizine (Zyrtec), desloratadine (Clarinex), fexofenadine (Allegra), and>loratadine (Claritin). Boo for me, then. I must be some sort of rare creature. For me, all those second generation antihistamines might as well be sugar pills, except for cetirizine, which might have a tiny impact (and possibly none at all). On the other hand, chlorpheniramine has a very noticeable effect, although I agree it is short-lived (I have to take it three times per day).