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Niacin Pathway Gene Linked to Motor Neuron Weakness Diseases
- Noaidi 1y agoThe gene is NAMPT (Nicotinamide phosphoribosyltransferase), which: "Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway."[1] [1] https://www.uniprot.org/uniprotkb/P43490/entry https://www.uniprot.org/uniprotkb/P43490/entry Full paper: https://www.science.org/doi/10.1126/sciadv.adx2407 https://www.science.org/doi/10.1126/sciadv.adx2407