Also not mentioned is that metformin can severely reduce B12 uptake. Lack of B12 can result in nervous system issues, and is very similar to neuropathy. You h

Also not mentioned is that metformin can severely reduce B12 uptake. Lack of B12 can result in nervous system issues, and is very similar to neuropathy. You have a store of several years of B12 so it can take quite a while before depletion sets in.