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My understanding has always been that you habituate to melatonin after a few days. Is this not true?

by tmountain 1y ago

submeta 1y ago
Not in my case. Never had this sleep quality. But maybe it's placebo after a few weeks? :)
- nervousvarun 1y ago
  FYI it's unlikely you will eventually develop a tolerance, but it's important to not increase dosage: https://newsnetwork.mayoclinic.org/discussion/mayo-clinic-minute-what-to-consider-before-using-melatonin-supplements-for-sleep https://newsnetwork.mayoclinic.org/discussion/mayo-clinic-mi...
  - amaccuish 1y ago
    The linked article doesn't mention tolerance at all? I don't believe there is any evidence out there to suggest that melatonin tolerance is a thing.
    - nervousvarun 1y ago
      You're right! Edited the post...thanks for pointing this out was actually a mistake on my part the article was about incorrect dosage which was the point I wanted to make.
      - amaccuish 1y ago
        Ahh then yes that's a super valid point. I've seen shops sell 10mg per tablet. 0.5mg already does the trick for me.
amaccuish 1y ago
I don't believe there is any evidence that you develop a tolerance. As a side note, Melatonin changed my life.
MobileVet 1y ago
Melatonin does have the potential for augmentation, but it isn’t a certainty or even the majority of people. Oddly, the result isn’t a loss of initial efficacy but instead a ‘wide awake at 3am’ situation.
rybosworld 1y ago
The body will develop a tolerance (or the reverse, a sensitization reaction) to just about any substance that's taken regularly due to homeostasis. However, so long as you're taking a dose that nudges some physiologic signal/need in the right direction, your body's response to the substance will be minimal. I'd be surprised if you can find anything this isn't true for. A lack of studies on what the tolerance looks like for a particular substance does not imply that tolerance does not form. In the case of melatonin: It's almost universally true that your sleep quality is worse than it was before once you stop taking it (for a few days at least). That's an indication that your body's equilibrium has changed from habitual use.

My understanding has always been that you habituate to melatonin after a few days. Is this not true?

submeta 1y ago

Not in my case. Never had this sleep quality. But maybe it's placebo after a few weeks? :)

nervousvarun 1y ago
FYI it's unlikely you will eventually develop a tolerance, but it's important to not increase dosage: https://newsnetwork.mayoclinic.org/discussion/mayo-clinic-minute-what-to-consider-before-using-melatonin-supplements-for-sleep https://newsnetwork.mayoclinic.org/discussion/mayo-clinic-mi...
- amaccuish 1y ago
  The linked article doesn't mention tolerance at all? I don't believe there is any evidence out there to suggest that melatonin tolerance is a thing.
  - nervousvarun 1y ago
    You're right! Edited the post...thanks for pointing this out was actually a mistake on my part the article was about incorrect dosage which was the point I wanted to make.
    - amaccuish 1y ago
      Ahh then yes that's a super valid point. I've seen shops sell 10mg per tablet. 0.5mg already does the trick for me.

amaccuish 1y ago

I don't believe there is any evidence that you develop a tolerance. As a side note, Melatonin changed my life.

MobileVet 1y ago

Melatonin does have the potential for augmentation, but it isn’t a certainty or even the majority of people. Oddly, the result isn’t a loss of initial efficacy but instead a ‘wide awake at 3am’ situation.

rybosworld 1y ago

The body will develop a tolerance (or the reverse, a sensitization reaction) to just about any substance that's taken regularly due to homeostasis. However, so long as you're taking a dose that nudges some physiologic signal/need in the right direction, your body's response to the substance will be minimal. I'd be surprised if you can find anything this isn't true for. A lack of studies on what the tolerance looks like for a particular substance does not imply that tolerance does not form. In the case of melatonin: It's almost universally true that your sleep quality is worse than it was before once you stop taking it (for a few days at least). That's an indication that your body's equilibrium has changed from habitual use.