5 ms·

Fuck me, is there anything fun that isn't nephrotoxic?

by anothernewdude 11mo ago

arthurcolle 11mo ago
Menu tonight is neurotoxic or nephrotoxic
- DoctorDabadedoo 11mo ago
  Would you have a fusion menu tasting? We are celebrating tonight.
  - Filligree 11mo ago
    Helium is pretty tasteless.
- archon810 11mo ago
  "Sir, just stop chewing on the menu and move on to the food."
- quitit 11mo ago
  I read this in the voice of GLaDOS
kybernetyk 11mo ago
shrooms
- Traubenfuchs 11mo ago
  think again https://www.sciencedirect.com/science/article/pii/S2211753918301490 https://www.sciencedirect.com/science/article/pii/S221175391...
  - j16sdiz 11mo ago
    Copying the abstract here, just in case anybody don't have access: Emily Austin, Hilary S. Myron, Richard K. Summerbell, Constance A. Mackenzie, Acute renal injury cause by confirmed Psilocybe cubensis mushroom ingestion, Medical Mycology Case Reports, Volume 23, 2019, Pages 55-57, ISSN 2211-7539, https://doi.org/10.1016/j.mmcr.2018.12.007 https://doi.org/10.1016/j.mmcr.2018.12.007. (https://www.sciencedirect.com/science/article/pii/S2211753918301490 https://www.sciencedirect.com/science/article/pii/S221175391...) Abstract: Psilocybe mushrooms are consumed for their hallucinogenic properties. Fortunately, there are relatively few adverse effects associated with their consumption. This is the first reported case of acute kidney injury (AKI) secondary to confirmed ingestion of Psilocybe cubensis mushroom. A 15-year-old male developed symptomatic AKI 36 h post-ingestion of Psilocybe cubensis mushrooms. He was admitted to hospital with hypertension, nausea and abdominal pain and a creatinine of 450 mmol/L. A sample of the crop of mushrooms was confirmed by mass spectrometry to contain psilocin. On day 5 post-admission, he was discharged home. Outpatient follow-up confirmed complete resolution of his renal function. Keywords: Psilocybe; Nephrotoxicity; Mushrooms; Kidney injury
    - 0_____0 11mo ago
      Kind of a cool read. They're not really sure why the P. cubensis was nephrotoxic. The sample they put through mass spec didn't contain the compound (Orellanine) that the clinical presentation lined up with, and none of the other youths who ate from that crop of mushrooms had subsequent problems. I wonder if there was an accidental polyculture issue, either with a different mushroom or a freak mutation that caused that particular shroom to synthesize toxic compounds. When growing directly from spores, you get mixed genetics, so your various mushrooms will grow slightly differently (if you want consistent genetics you grow clones from an isolate via agar plate or tissue sample from fruiting body).
Traubenfuchs 11mo ago
PDE5 (viagra, cyalis) improve the health of the cardiovascular system, thus improve kidney health and I greatly enjoy them. This is well researched and just like with semaglutide I believe a big part of the population should take daily tadalafil. Better cardiovascular health, more erections and many positive downstream effects (lower E:T ratio, weight loss) that are beyond the scope of this comment.
- iamacyborg 11mo ago
  People should probably try improve their CV health via exercise, rather than pills, wherever possible.
  - mulnz 11mo ago
    Why?
    - iamacyborg 11mo ago
      Because of all the other physiological and mental benefits that come from the exercise that the pill won’t give you?
      - smokel 11mo ago
        It might be empirically sound, but it does not make a priori sense that exercising a body will improve it. If I use almost any object in the universe frequently, it typically degrades rather than improves. The health benefits of exercise are most likely due to improved blood flow and related physiological effects. In principle, pills could theoretically achieve similar outcomes by enhancing circulation or other underlying mechanisms. Not taking sides here, just reasoning out loud.
        iamacyborg 11mo ago
        In the context of running, physiological benefits I’m familiar with include improvements to bone density and joint health, increased capillarisation and therefore blood flow in the muscles and improved energy efficiency in cells. I suspect you’re not going to find a pill or combination of pills that can achieve those outcomes. And again, we’re ignoring the mental health benefits.
layer8 11mo ago
Uranium ingestion is fun?

Fuck me, is there anything fun that isn't nephrotoxic?

arthurcolle 11mo ago

Menu tonight is neurotoxic or nephrotoxic

DoctorDabadedoo 11mo ago
Would you have a fusion menu tasting? We are celebrating tonight.
- Filligree 11mo ago
  Helium is pretty tasteless.
archon810 11mo ago
"Sir, just stop chewing on the menu and move on to the food."
quitit 11mo ago
I read this in the voice of GLaDOS

kybernetyk 11mo ago

shrooms

Traubenfuchs 11mo ago
think again https://www.sciencedirect.com/science/article/pii/S2211753918301490 https://www.sciencedirect.com/science/article/pii/S221175391...
- j16sdiz 11mo ago
  Copying the abstract here, just in case anybody don't have access: Emily Austin, Hilary S. Myron, Richard K. Summerbell, Constance A. Mackenzie, Acute renal injury cause by confirmed Psilocybe cubensis mushroom ingestion, Medical Mycology Case Reports, Volume 23, 2019, Pages 55-57, ISSN 2211-7539, https://doi.org/10.1016/j.mmcr.2018.12.007 https://doi.org/10.1016/j.mmcr.2018.12.007. (https://www.sciencedirect.com/science/article/pii/S2211753918301490 https://www.sciencedirect.com/science/article/pii/S221175391...) Abstract: Psilocybe mushrooms are consumed for their hallucinogenic properties. Fortunately, there are relatively few adverse effects associated with their consumption. This is the first reported case of acute kidney injury (AKI) secondary to confirmed ingestion of Psilocybe cubensis mushroom. A 15-year-old male developed symptomatic AKI 36 h post-ingestion of Psilocybe cubensis mushrooms. He was admitted to hospital with hypertension, nausea and abdominal pain and a creatinine of 450 mmol/L. A sample of the crop of mushrooms was confirmed by mass spectrometry to contain psilocin. On day 5 post-admission, he was discharged home. Outpatient follow-up confirmed complete resolution of his renal function. Keywords: Psilocybe; Nephrotoxicity; Mushrooms; Kidney injury
  - 0_____0 11mo ago
    Kind of a cool read. They're not really sure why the P. cubensis was nephrotoxic. The sample they put through mass spec didn't contain the compound (Orellanine) that the clinical presentation lined up with, and none of the other youths who ate from that crop of mushrooms had subsequent problems. I wonder if there was an accidental polyculture issue, either with a different mushroom or a freak mutation that caused that particular shroom to synthesize toxic compounds. When growing directly from spores, you get mixed genetics, so your various mushrooms will grow slightly differently (if you want consistent genetics you grow clones from an isolate via agar plate or tissue sample from fruiting body).

Traubenfuchs 11mo ago

PDE5 (viagra, cyalis) improve the health of the cardiovascular system, thus improve kidney health and I greatly enjoy them. This is well researched and just like with semaglutide I believe a big part of the population should take daily tadalafil. Better cardiovascular health, more erections and many positive downstream effects (lower E:T ratio, weight loss) that are beyond the scope of this comment.

iamacyborg 11mo ago
People should probably try improve their CV health via exercise, rather than pills, wherever possible.
- mulnz 11mo ago
  Why?
  - iamacyborg 11mo ago
    Because of all the other physiological and mental benefits that come from the exercise that the pill won’t give you?
    - smokel 11mo ago
      It might be empirically sound, but it does not make a priori sense that exercising a body will improve it. If I use almost any object in the universe frequently, it typically degrades rather than improves. The health benefits of exercise are most likely due to improved blood flow and related physiological effects. In principle, pills could theoretically achieve similar outcomes by enhancing circulation or other underlying mechanisms. Not taking sides here, just reasoning out loud.
      - iamacyborg 11mo ago
        In the context of running, physiological benefits I’m familiar with include improvements to bone density and joint health, increased capillarisation and therefore blood flow in the muscles and improved energy efficiency in cells. I suspect you’re not going to find a pill or combination of pills that can achieve those outcomes. And again, we’re ignoring the mental health benefits.

layer8 11mo ago

Uranium ingestion is fun?