4 ms·

Well that's depressing. My biggest fear, and this isn't a bad setup for a joke, is early-onset Alzheimers. I don't think I'm especially high-risk for it, but I

Well that's depressing. My biggest fear, and this isn't a bad setup for a joke, is early-onset Alzheimers. I don't think I'm especially high-risk for it, but I did have a single great-grandfather who got it so technically it does run in my family. It seems so horrible, having your brain sort of deteriorate and losing all your memories, and being a burden to everyone. Ideally I never get it, but if I do get I hope it's in like my late 90's, or even better by the time I get it they already have a cure, though the fact this might not work for humans makes me a little sad.

ineedaj0b 1y ago
there’s some interesting treatment in china that seems promising. something about unclogging drains in the neck. friend told me it looked ‘possible’. the whole western field is 15-20 years behind because some researcher lied about plaque data and everyone spent all their time chasing the lead. I think you’ll see useful therapies in 15-20 years from the west, maybe sooner if all the some ai hype pans out. or the Chinese thing turns out to work! can’t tell myself. there’s probably an American who will try it at some point and publish a case study. Very tough to judge Chinese papers.. here’s an overview: https://pmc.ncbi.nlm.nih.gov/articles/PMC12121576/ https://pmc.ncbi.nlm.nih.gov/articles/PMC12121576/
- JumpCrisscross 1y ago
  “Despite this rapid adoption and ‘miraculous effects’ from non-academic sources, no other country has reported clinical applications or clinical trials of LVA for AD treatment so far, raising questions about its mechanism, efficacy and implications.” China has an actual medical establishment. The fact that the treat this as homeopathy should give one pause.
  - ineedaj0b 1y ago
    fine fine. Let me speak to you like you're a colleague and not a hn commenter that you can be upfront with: As a practicing clinician, I must express significant reservations regarding therapeutic agents emerging from China, particularly those rooted in traditional Chinese medicine (TCM). In the absence of rigorous, peer-reviewed validation through randomized controlled trials (RCTs) conducted under Western regulatory standards, such interventions are frequently met with skepticism within the medical community. The prevailing perception among Western practitioners is that TCM-based therapies often lack robust empirical evidence, bearing a conceptual resemblance to homeopathic modalities, which are similarly contentious due to limited mechanistic clarity and inconsistent clinical outcomes. When considering novel pharmacotherapies developed in China, especially those in early-phase clinical trials or lacking approval from regulatory bodies such as the FDA or EMA, the Western medical establishment tends to approach them with caution. For instance, a colleague proposing a TCM-derived treatment would likely feel compelled to provide substantial reassurances to counter the inherent skepticism surrounding its efficacy and safety profile. This is not to dismiss the potential of such innovations outright, but rather to underscore the critical need for transparent, reproducible data to substantiate claims of therapeutic breakthroughs, particularly when these agents remain confined to regional use without broader dissemination in Western markets. I used to wonder why drs never comment on this site and I'm starting to understand why
adastra22 1y ago
And what? (Or was that the joke?)
- tombert 1y ago
  Nope, that wasn't intended to be a joke, I just forgot to finish the sentence. Edited.

ineedaj0b 1y ago

there’s some interesting treatment in china that seems promising. something about unclogging drains in the neck. friend told me it looked ‘possible’. the whole western field is 15-20 years behind because some researcher lied about plaque data and everyone spent all their time chasing the lead. I think you’ll see useful therapies in 15-20 years from the west, maybe sooner if all the some ai hype pans out. or the Chinese thing turns out to work! can’t tell myself. there’s probably an American who will try it at some point and publish a case study. Very tough to judge Chinese papers.. here’s an overview: https://pmc.ncbi.nlm.nih.gov/articles/PMC12121576/ https://pmc.ncbi.nlm.nih.gov/articles/PMC12121576/

JumpCrisscross 1y ago
“Despite this rapid adoption and ‘miraculous effects’ from non-academic sources, no other country has reported clinical applications or clinical trials of LVA for AD treatment so far, raising questions about its mechanism, efficacy and implications.” China has an actual medical establishment. The fact that the treat this as homeopathy should give one pause.
- ineedaj0b 1y ago
  fine fine. Let me speak to you like you're a colleague and not a hn commenter that you can be upfront with: As a practicing clinician, I must express significant reservations regarding therapeutic agents emerging from China, particularly those rooted in traditional Chinese medicine (TCM). In the absence of rigorous, peer-reviewed validation through randomized controlled trials (RCTs) conducted under Western regulatory standards, such interventions are frequently met with skepticism within the medical community. The prevailing perception among Western practitioners is that TCM-based therapies often lack robust empirical evidence, bearing a conceptual resemblance to homeopathic modalities, which are similarly contentious due to limited mechanistic clarity and inconsistent clinical outcomes. When considering novel pharmacotherapies developed in China, especially those in early-phase clinical trials or lacking approval from regulatory bodies such as the FDA or EMA, the Western medical establishment tends to approach them with caution. For instance, a colleague proposing a TCM-derived treatment would likely feel compelled to provide substantial reassurances to counter the inherent skepticism surrounding its efficacy and safety profile. This is not to dismiss the potential of such innovations outright, but rather to underscore the critical need for transparent, reproducible data to substantiate claims of therapeutic breakthroughs, particularly when these agents remain confined to regional use without broader dissemination in Western markets. I used to wonder why drs never comment on this site and I'm starting to understand why

adastra22 1y ago

And what? (Or was that the joke?)

tombert 1y ago
Nope, that wasn't intended to be a joke, I just forgot to finish the sentence. Edited.