3 ms·

Clinical trial: https://en.wikipedia.org/wiki/Clinical_trial https://en.wikipedia.org/wiki/Clinical_trial Randomized controlled trial: https://en.wikipedia.or

Clinical trial: https://en.wikipedia.org/wiki/Clinical_trial https://en.wikipedia.org/wiki/Clinical_trial Randomized controlled trial: https://en.wikipedia.org/wiki/Randomized_controlled_trial https://en.wikipedia.org/wiki/Randomized_controlled_trial Glossary of experimental design: https://en.wikipedia.org/wiki/Glossary_of_experimental_design https://en.wikipedia.org/wiki/Glossary_of_experimental_desig... > Multi-arm multi-stage (MAMS) platform trials by the MRC Clinical Trials Unit at UCL — an overview of the advantages of MAMS trials, with teaching material Is this like multi-armed bandit which marketing runs instead of A/B sometimes? Multi-armed bandit: https://en.wikipedia.org/wiki/Multi-armed_bandit https://en.wikipedia.org/wiki/Multi-armed_bandit > Cluster randomized trials by the NIH Pragmatic Trials Collaboratory Cluster randomized trials: https://en.wikipedia.org/wiki/Cluster-randomised_controlled_trial https://en.wikipedia.org/wiki/Cluster-randomised_controlled_... > Crossover trials by the Cochrane Training Handbook Crossover study, Crossover Trial: https://en.wikipedia.org/wiki/Crossover_study https://en.wikipedia.org/wiki/Crossover_study But that's a different usage of the word "Crossover" than "Crossover" as an observed process and method of adaptation and optimization? Crossover (evolutionary algorithm) https://en.wikipedia.org/wiki/Crossover_(evolutionary_algorithm) https://en.wikipedia.org/wiki/Crossover_(evolutionary_algori...

westurner 1y ago
"Matching patients to clinical trials with large language models" (2025) https://news.ycombinator.com/item?id=42190128 https://news.ycombinator.com/item?id=42190128 "TrialGPT"
westurner 1y ago
From 2019 re: "post-market" clinical data which is collected after clinical trials and regulatory approval: https://news.ycombinator.com/item?id=21235358 https://news.ycombinator.com/item?id=21235358 : > We really could get more out of this data through international collaboration and through linked data (e.g. URIs for columns). See: "Open, and Linked, FDA data" https://github.com/FDA/openfda/issues/5#issuecomment-5392966 https://github.com/FDA/openfda/issues/5#issuecomment-5392966... and "ENH: Adverse Event Count / 'Use' Count Heatmap" https://github.com/FDA/openfda/issues/49 https://github.com/FDA/openfda/issues/49 > With sales/usage counts, we'd have a denominator with which we could calculate relative hazard.
- westurner 1y ago
  FHIR is a standard for sharing health data. FHIR would be useful for sharing collected clinical data - for example vitals - with patients and their other providers if they choose. FHIR could be useful for collecting chart data from clinical trial participants. FHIR can be represented in JSON-LD, which is Linked Data in JSON such that no XML parsing is required. Re: FHIR JSON-LD https://news.ycombinator.com/item?id=42230270 https://news.ycombinator.com/item?id=42230270 : > /? awesome clinical open source: https://www.google.com/search?q=awesome+clinical+open+source https://www.google.com/search?q=awesome+clinical+open+source

westurner 1y ago

"Matching patients to clinical trials with large language models" (2025) https://news.ycombinator.com/item?id=42190128 https://news.ycombinator.com/item?id=42190128 "TrialGPT"

westurner 1y ago

From 2019 re: "post-market" clinical data which is collected after clinical trials and regulatory approval: https://news.ycombinator.com/item?id=21235358 https://news.ycombinator.com/item?id=21235358 : > We really could get more out of this data through international collaboration and through linked data (e.g. URIs for columns). See: "Open, and Linked, FDA data" https://github.com/FDA/openfda/issues/5#issuecomment-5392966 https://github.com/FDA/openfda/issues/5#issuecomment-5392966... and "ENH: Adverse Event Count / 'Use' Count Heatmap" https://github.com/FDA/openfda/issues/49 https://github.com/FDA/openfda/issues/49 > With sales/usage counts, we'd have a denominator with which we could calculate relative hazard.

westurner 1y ago
FHIR is a standard for sharing health data. FHIR would be useful for sharing collected clinical data - for example vitals - with patients and their other providers if they choose. FHIR could be useful for collecting chart data from clinical trial participants. FHIR can be represented in JSON-LD, which is Linked Data in JSON such that no XML parsing is required. Re: FHIR JSON-LD https://news.ycombinator.com/item?id=42230270 https://news.ycombinator.com/item?id=42230270 : > /? awesome clinical open source: https://www.google.com/search?q=awesome+clinical+open+source https://www.google.com/search?q=awesome+clinical+open+source