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Nobel Prize in Physiology or Medicine 2025
- A_D_E_P_T 1y agoIt's a win for nominative determinism. The name Shimon, in Japanese, directly translates to something like "Determined Scholar." It's also a fairly weird and old fashioned name. The sort of thing that would have been in style 120 years ago. (Meiji and early Taisho era.) Japanese names today are usually less literal.
- deleted 1y ago[deleted]
- coef2 1y agoHis name could be interpreted as "aspiring to be a scholar". I guess he's done an exceptional job living up to it.
- matsemann 1y agoI love how Nobel Prize always have a "popular information" with nice layman description of what was discovered and why it was important. From the sidebar: https://www.nobelprize.org/prizes/medicine/2025/popular-information/ https://www.nobelprize.org/prizes/medicine/2025/popular-info...
- NeutralForest 1y agoThere's usually two pieces, a short one that can be taken as is for the general press and another which goes more in depth at a university level I would say.
- haunter 1y agoThere are actually three The press release https://www.nobelprize.org/prizes/medicine/2025/press-release/ https://www.nobelprize.org/prizes/medicine/2025/press-releas... The popular science article https://www.nobelprize.org/prizes/medicine/2025/popular-information/ https://www.nobelprize.org/prizes/medicine/2025/popular-info... And an advanced scientific paper usually written by the members of the commitee https://www.nobelprize.org/uploads/2025/10/advanced-medicineprize2025.pdf https://www.nobelprize.org/uploads/2025/10/advanced-medicine...
- NeutralForest 1y agoIndeed!
- falcor84 1y agoAnd then later on there's of course the recipient's Nobel lecture, most of which are fantastic.
- haunter 1y agoAh it's the Nobel Prize week! If anyone curious about this week's schedule: Tuesday: physics. Wednesday: chemistry. Thursday: literature. Friday: peace. Monday: economics.
- mongol 1y ago[flagged]
- haunter 1y agoHere are the current favorites accross the betting sites, I mean Trump has a decent chance https://files.catbox.moe/xc1ik1.png https://files.catbox.moe/xc1ik1.png (NATO is a funny one too lol)
- phrotoma 1y agoholy fuck people will bet on pretty much anything I guess huh?
- andrewinardeer 1y agoI bet you they won't.
- triceratops 1y agoI will take that bet. It's very easy for me to win.
- deleted 1y ago[deleted]
- koakuma-chan 1y agofiles.catbox.moe has a security policy called HTTP Strict Transport Security (HSTS), which means that Firefox can only connect to it securely. You can’t add an exception to visit this site. Why is Firefix blocking it? Is HSTS somehow bad? Oh there's something with their certificate
- slider22 1y agoIn the past here on HN, someone spoke of a set of books that were an incredible resource on the body’s immune response. Does anyone know which books those were? I’m assuming they will get an update to include info on T-reg.
- fabian2k 1y agoThese discoveries are old enough to be in the textbooks already. Not sure what would be good popular science books. There is quite a lot on the immune system in the Alberts (Molecular Biology of the Cell), but that is maybe too much without solid biology background knowledge. The typical textbook is the Janeway (Immunology), but that's certainly too much. What I liked as an introductory textbook in general was Campbell Biology, but that covers essentially all of Biology. There is a chapter on the immune system as well. All those books are horribly expensive in the US, and still quite expensive in other countries, though.
- pazimzadeh 1y agoJaneway's Immunobiology is the classic textbook Here's the 8th edition (2012): https://www.dropbox.com/scl/fi/dx0egzl37bfsl9ur6zsg1/janeway-s-immunobiology.pdf?rlkey=b1pg0xkr22kkrlivfidiu91bl&dl=0 https://www.dropbox.com/scl/fi/dx0egzl37bfsl9ur6zsg1/janeway...
- jsenn 1y agoI don’t know the post you’re referring to but I highly recommend How the Immune System Works by Lauren Sompayrac. It explains the interesting parts without getting bogged down in the details of every signalling pathway, but without dumbing things down too much.
- blackbear_ 1y agoAs a general introduction I quite like this one: https://shop-us.kurzgesagt.org/products/immune-a-journey-into-the-mysterious-system-that-keeps-you-alive https://shop-us.kurzgesagt.org/products/immune-a-journey-int...
- smath 1y ago
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- globalhsbc 1y ago[dead]
- marcelotournier 1y agoFirst pattern that comes into mind after reading about a gene called "Foxp3" and immune targets: Man frantically shakes whole body, then raises dramatically his fist and screams: - FOX...
- aspenmayer 1y agoMetal Gear..? https://breezewiki.com/metalgear/wiki/FOXDIE https://breezewiki.com/metalgear/wiki/FOXDIE > FOXDIE (originally rendered as FoxDie) was an engineered retrovirus developed by the DIA for the Pentagon. It was programmed to kill specific people by recognizing a person's DNA, causing cardiac arrest.
- astrange 1y agohttps://en.wikipedia.org/wiki/Sonic_hedgehog_protein https://en.wikipedia.org/wiki/Sonic_hedgehog_protein But: https://en.wikipedia.org/wiki/Sonic_hedgehog_protein#Former_controversy_surrounding_name https://en.wikipedia.org/wiki/Sonic_hedgehog_protein#Former_...
- jelsisi 1y agoVery excited to live in a timeline where autoimmune diseases could be cured. 40 people are already in remission from Lupus in a trial conducted last year.
- osnium123 1y agoIt’s interesting that two of the two American recipients weren’t recognized by other awards like membership in the National Academy of Sciences or the National Academy of Medicine. Truly black horse candidates which makes this fun.
- dangle1 1y agoFunny anecdote that Dr. Brunkow thought she was being spammed when the Nobel Committee tried to inform her: >Brunkow, meanwhile, got the news of her prize from an AP photographer who came to her Seattle home in the early hours of the morning. She said she had ignored the earlier call from the Nobel Committee. “My phone rang and I saw a number from Sweden and thought: ‘That’s just, that’s spam of some sort.’” https://www.oregonlive.com/pacific-northwest-news/2025/10/scientist-who-graduated-from-portland-high-school-wins-nobel-prize-in-medicine.html https://www.oregonlive.com/pacific-northwest-news/2025/10/sc...
- tombert 1y agoI can’t say I would react too differently. There are so many emails or phone calls claiming you’ve won a big award or sum of money that end up being scams.
- pdxandi 1y agoAm I understanding correctly that this Nobel prize is for work that was completed over 20 years ago? I'm not a biologist but it sounds like they discovered regulatory T cells together, which sounds relatively major. Is it typical for a Nobel prize to lag that kind of discovery for decades? Or is it only now that we understand how major the discovery was? Or maybe I'm just misunderstanding the discovery and the timeline.
- osnium123 1y agoYes, many Nobel prizes are awarded for work that was completed decades ago in part to ensure that the work passes the test of time.
- serioussecurity 1y agoHighs had a delay of 49 years from paper to prize, though he got the prize the year after his theory was experimentally confirmed.
- abdullahkhalids 1y agoAt least in Physics, on average every year there is more than one discovery that is worth a Nobel prize. So there is an increasing backlog of people who should get a Nobel prize. You can look at the list and check that people in the 1920s got their prize about 15 years after their work [1]. But recently people have been getting it about 30-40 years after. [1] https://en.wikipedia.org/wiki/List_of_Nobel_laureates_in_Physics https://en.wikipedia.org/wiki/List_of_Nobel_laureates_in_Phy...
- pazimzadeh 1y agoTolerance is one of the coolest things in immunology. This Nobel is about peripheral tolerance, but you should first appreciate central tolerance to understand why it matters. After the stem cell phase, just about every cell in your body gradually becomes locked in a specific program (differentiated/specialized) so that your heart cells lose the ability to express say lung proteins, and vice versa. But in order to train your immune cells not to react to self, during development some cells in the thymus are allowed to express self proteins from every type of tissue, so your thymus expresses neural, heart, lung, etc.. proteins. Any T-cells that react with this self proteins are deleted. https://en.wikipedia.org/wiki/Autoimmune_regulator https://en.wikipedia.org/wiki/Autoimmune_regulator However, central tolerance is not that efficient, so peripheral tolerance takes care of the T-cells which escaped central tolerance. A major way that this is accomplished is by counterintuitively maintaining a population of self-specific T-cells called regulatory T-cells which put the breaks on immune reactions in the presence of self antigen (antigen = 3D shape of protein or sugar). In many ways tolerance is actually the default reaction of the immune system - you encounter too many foreign objects (in food, air, etc) to react to everything. That's why vaccines have an "adjuvant" compound which tells your immune system to react.
- TOMDM 1y agoThis is fascinating. If one had an infected thymus, does this mean that immune cells would be eliminated for attacking the infection, and thus the immune system be tuned to ignore the present infection?
- pazimzadeh 1y agoI've never thought or heard of that, but theoretically yes? However most of this happens before birth, and thymus infection is pretty unlikely at that point - the baby is protected by the mom's antibodies and is also physically sequestered. If the unborn baby has a thymus infection I would be more worried about what the mother has.
- utbabya 1y agoAm I the only one who see the title immune system suppression and think weapon?