5 ms·

I'd love the current generation of POSs in power to die off naturally before those advancements will be applied, thank you.

JumpCrisscross 1y ago
> love the current generation of POSs in power to die off naturally before those advancements will be applied These treatments aren't panaceas. The benefit would almost certainly accrue inversely with age.
mupuff1234 1y ago
To make room for a new generation of POSs?
carabiner 1y ago
In 200 years, we're going to look at our lack of checks and balances against gerontocracy as naive as trusting monarchy in the middle ages.
- luxuryballs 1y ago
  we may alternatively end up with even older elders because of general lifespan increases, it just so happens people with more experience are older, if you think older people being in charge is bad just wait until you see how the younger ones do
computerphage 1y ago
[flagged]
- SirFatty 1y ago
  [flagged]
muhammedbash 1y ago
Too late... Putin is already all over this. No need for organ transplants :) 150 is the new 70
- layer8 1y ago
  This is in reference to recent events: https://www.theguardian.com/world/2025/sep/05/healthy-living-science-doctors-vladimir-putin-pursuit-of-longevity-xi-jinping https://www.theguardian.com/world/2025/sep/05/healthy-living...
jayd16 1y ago
I do wonder how the psychology of humanity will change once you can't wait for someone to die, and conversely, you can't expect to die before consequences catch up to you.
- JumpCrisscross 1y ago
  > once you can't wait for someone to die, and consequently, you can't expect to die before consequences catch up to you People will still die, even in a world without ageing, which this treatment doesn't promise.
  - Retric 1y ago
    The risk of death per year increasing with number of years lived is aging. Without that people have lived longer are more likely to have lower risks of death per year. And thus older people in such a society would on average live longer.
    - dandellion 1y ago
      Unless it also cures cancer a more likely outcome is that people who get the treatment will just stay young until they get cancer and die. Also, as I understand it cancer also slows down in old age, so staying younger could mean faster cancers possibly negating some of the gains from the decreased aging.
      - Retric 1y ago
        Aging is more than just looking old. If someone has an increased risk of death per year from cancer or whatever because something is failing over time they are still aging. If the rate per year stays the same IE being 20 or 20,000 has no impact on your risks of cancer each year then someone that’s 20,000 likely takes very few other risks and is more likely to live another 20,000 years than the random 20 year old.
      - MagicMoonlight 1y ago
        Cancer is primarily caused by aging, so in this world there likely wouldn’t be much cancer outside of the deliberate cancers caused by things like smoking
asdfman123 1y ago
Fundamental attribution error. It's the system which requires people be POSes to maintain their position. There are a million problems that will arise if people won't be able to die and that's just another one of them.
rmah 1y ago
If you think the next generation will be any better, I have bad news for you...
thomassmith65 1y ago
This article, like most about medical breakthroughs, is probably nonsense. And that's good because, for my part, I plan to shuffle off this mortal coil in time not to see America elect Nick Fuentes as President.
- chasil 1y ago
  I don't think that the assertions are nonsense, but I don't understand how this works. I have heard variants on this assertion: "Two of the most prominent purported underlying causes of aging are chronic inflammation and senescent cells." One thing that surprises me is that telomeres aren't mentioned. I also don't understand how this is happening (is apoptosis somehow triggered?): "Now, the Academy researchers demonstrate that SRCs reduce senescent cells, measured using a blue dye called SA-β-Gal, in multiple organs, including the brain, heart, and lungs." The main mechanism of action appears to be: "The therapeutic efficacy of MPCs is largely attributed to their paracrine actions, with exosomes playing a pivotal role in mediating these effects." The researchers do not appear to fully understand how this is happening: "Among the diverse geroprotective functions of SRCs in the brain and ovary, the restorative effect of SRC-derived exosomes on aged cells and their surroundings emerges as a key mechanism. Rejuvenation of aged cells by exosomes likely involves multiple pathways and targets."
  - deleted 1y ago
    [deleted]
- esseph 1y ago
  It really seems like things are heading in that direction :/
mikestew 1y ago
Tell them it's an anti-aging vaccine.
bitwize 1y ago
Contrariwise, neither Hitler nor Stalin died of old age. Societies have ways of dealing with tyrants.
- libraryofbabel 1y ago
  Trite, and wrong. Stalin died of a stroke at 74. To take just two more examples, Mao and Franco both died at 82, also of natural causes.
- southernplaces7 1y ago
  Stalin died literally in his bed, secure and surrounded by dozens of protecting bodyguards who ironically were so afraid to bother him that his stroke wen't unattended for hours after he'd had it. And in dying at 74, he enjoyed what despite the hard toll of heavy smoking, drinking, eating richly, and deprivation in his youth, was a pretty decent lifespan by the standards of his time. Hitler ultimately died from the sheer gambler's recklessness of reaching for far too much that belonged to too many other powers, and being burned by all the consequences. Had he not started a multi-front world war against almost every single one of the world's other major nations, he could have stayed safely in power as Germany's beloved dictator right up until any old age he managed to reach (as Franco pulled off by much more wisely focusing on consolidating domestic power and avoiding wars) Societies do have ways of dealing with tyrants, yes, and mostly it's just by rewarding them with more. The bad parts mostly happen to utterly foolish tyrants who make tremendous missteps.
Razengan 1y ago
Enter a generation of spoiled nepo babies with AI Terminators to put them in power and medical immortality to keep them in power.
namuol 1y ago
“To those who can hear me, I say - do not despair. The misery that is now upon us is but the passing of greed - the bitterness of men who fear the way of human progress. The hate of men will pass, and dictators die, and the power they took from the people will return to the people. And so long as men die, liberty will never perish…”
torstenvl 1y ago
Wishing harm on someone is not acceptable behavior on HN. Ideological warfare is not acceptable behavior on HN. Please do not do this here.
- codesnik 1y ago
  it kinda looks like you've assumed my "ideology", or even a country. Also, to die of natural causes, you know, for some people in some positions is actually a good wish. And we all will be there, I just really hope to outlive particular people.
  - jibal 1y ago
    The comment you responded to is one of many grossly intellectually dishonest ones in this discussion.
AmbroseBierce 1y ago
What will that achieve? Next generation with no doubt will have their own POSs, their offspring think pretty much like them already, there is no way out of this vicious cycle. I don't really blame humans in particular, a bear can eat it's prey alive and feel nothing at all about it, and many other similar examples of cruelty exist in nature, many even eat their own species in special circumstances, despite that I don't consider any of them evil. Nothing short of a highly contagious virus that affects the brain and makes us more emphatic (with no other side effect) would break the cycle, but that's just sci-fi talk.
- wolfram74 1y ago
  What, did you read Adrian Tchaikovsky's Children of Time recently?
  - AmbroseBierce 1y ago
    No idea who that is, but it's not particularly challenging to realize evolution doesn't overall favor empathy -even if it played some role-, sometimes it's the full opposite, sometimes is punished ("no good deed goes unpunished"), firemen are the most prone to burns, the equivalent it's true for many other altruistic endeavors, including rare occasional ones unlike firemen. It's also not particularly challenging to see society lacks any intrinsic defence from the most ruthless and greedy from advancing in any given power structure inside of it, it's a long term damage so it's abstracted away while more immediate issues take presedence, it's in our DNA to give too priority to immediate threats, while long term problems such as this don't make the top 10 (another example being climate change, etc)
- codesnik 1y ago
  I wonder if somebody already experiments on altering toxoplasmosis
ben_w 1y ago
Sadly, we will never run out of evil people regardless. For every evil old person today, there's a handful of evil younger people behind them, just because of demographics.
henriquenunez 1y ago
xi jinping and puting already said

JumpCrisscross 1y ago

> love the current generation of POSs in power to die off naturally before those advancements will be applied These treatments aren't panaceas. The benefit would almost certainly accrue inversely with age.

mupuff1234 1y ago

To make room for a new generation of POSs?

carabiner 1y ago

In 200 years, we're going to look at our lack of checks and balances against gerontocracy as naive as trusting monarchy in the middle ages.

luxuryballs 1y ago
we may alternatively end up with even older elders because of general lifespan increases, it just so happens people with more experience are older, if you think older people being in charge is bad just wait until you see how the younger ones do

computerphage 1y ago

[flagged]

SirFatty 1y ago
[flagged]

muhammedbash 1y ago

Too late... Putin is already all over this. No need for organ transplants :) 150 is the new 70

layer8 1y ago
This is in reference to recent events: https://www.theguardian.com/world/2025/sep/05/healthy-living-science-doctors-vladimir-putin-pursuit-of-longevity-xi-jinping https://www.theguardian.com/world/2025/sep/05/healthy-living...

jayd16 1y ago

I do wonder how the psychology of humanity will change once you can't wait for someone to die, and conversely, you can't expect to die before consequences catch up to you.

JumpCrisscross 1y ago
> once you can't wait for someone to die, and consequently, you can't expect to die before consequences catch up to you People will still die, even in a world without ageing, which this treatment doesn't promise.
- Retric 1y ago
  The risk of death per year increasing with number of years lived is aging. Without that people have lived longer are more likely to have lower risks of death per year. And thus older people in such a society would on average live longer.
  - dandellion 1y ago
    Unless it also cures cancer a more likely outcome is that people who get the treatment will just stay young until they get cancer and die. Also, as I understand it cancer also slows down in old age, so staying younger could mean faster cancers possibly negating some of the gains from the decreased aging.
    - Retric 1y ago
      Aging is more than just looking old. If someone has an increased risk of death per year from cancer or whatever because something is failing over time they are still aging. If the rate per year stays the same IE being 20 or 20,000 has no impact on your risks of cancer each year then someone that’s 20,000 likely takes very few other risks and is more likely to live another 20,000 years than the random 20 year old.
    - MagicMoonlight 1y ago
      Cancer is primarily caused by aging, so in this world there likely wouldn’t be much cancer outside of the deliberate cancers caused by things like smoking

asdfman123 1y ago

Fundamental attribution error. It's the system which requires people be POSes to maintain their position. There are a million problems that will arise if people won't be able to die and that's just another one of them.

rmah 1y ago

If you think the next generation will be any better, I have bad news for you...

thomassmith65 1y ago

This article, like most about medical breakthroughs, is probably nonsense. And that's good because, for my part, I plan to shuffle off this mortal coil in time not to see America elect Nick Fuentes as President.

chasil 1y ago
I don't think that the assertions are nonsense, but I don't understand how this works. I have heard variants on this assertion: "Two of the most prominent purported underlying causes of aging are chronic inflammation and senescent cells." One thing that surprises me is that telomeres aren't mentioned. I also don't understand how this is happening (is apoptosis somehow triggered?): "Now, the Academy researchers demonstrate that SRCs reduce senescent cells, measured using a blue dye called SA-β-Gal, in multiple organs, including the brain, heart, and lungs." The main mechanism of action appears to be: "The therapeutic efficacy of MPCs is largely attributed to their paracrine actions, with exosomes playing a pivotal role in mediating these effects." The researchers do not appear to fully understand how this is happening: "Among the diverse geroprotective functions of SRCs in the brain and ovary, the restorative effect of SRC-derived exosomes on aged cells and their surroundings emerges as a key mechanism. Rejuvenation of aged cells by exosomes likely involves multiple pathways and targets."
- deleted 1y ago
  [deleted]
esseph 1y ago
It really seems like things are heading in that direction :/

mikestew 1y ago

Tell them it's an anti-aging vaccine.

bitwize 1y ago

Contrariwise, neither Hitler nor Stalin died of old age. Societies have ways of dealing with tyrants.

libraryofbabel 1y ago
Trite, and wrong. Stalin died of a stroke at 74. To take just two more examples, Mao and Franco both died at 82, also of natural causes.
southernplaces7 1y ago
Stalin died literally in his bed, secure and surrounded by dozens of protecting bodyguards who ironically were so afraid to bother him that his stroke wen't unattended for hours after he'd had it. And in dying at 74, he enjoyed what despite the hard toll of heavy smoking, drinking, eating richly, and deprivation in his youth, was a pretty decent lifespan by the standards of his time. Hitler ultimately died from the sheer gambler's recklessness of reaching for far too much that belonged to too many other powers, and being burned by all the consequences. Had he not started a multi-front world war against almost every single one of the world's other major nations, he could have stayed safely in power as Germany's beloved dictator right up until any old age he managed to reach (as Franco pulled off by much more wisely focusing on consolidating domestic power and avoiding wars) Societies do have ways of dealing with tyrants, yes, and mostly it's just by rewarding them with more. The bad parts mostly happen to utterly foolish tyrants who make tremendous missteps.

Razengan 1y ago

Enter a generation of spoiled nepo babies with AI Terminators to put them in power and medical immortality to keep them in power.

namuol 1y ago

“To those who can hear me, I say - do not despair. The misery that is now upon us is but the passing of greed - the bitterness of men who fear the way of human progress. The hate of men will pass, and dictators die, and the power they took from the people will return to the people. And so long as men die, liberty will never perish…”

torstenvl 1y ago

Wishing harm on someone is not acceptable behavior on HN. Ideological warfare is not acceptable behavior on HN. Please do not do this here.

codesnik 1y ago
it kinda looks like you've assumed my "ideology", or even a country. Also, to die of natural causes, you know, for some people in some positions is actually a good wish. And we all will be there, I just really hope to outlive particular people.
- jibal 1y ago
  The comment you responded to is one of many grossly intellectually dishonest ones in this discussion.

AmbroseBierce 1y ago

What will that achieve? Next generation with no doubt will have their own POSs, their offspring think pretty much like them already, there is no way out of this vicious cycle. I don't really blame humans in particular, a bear can eat it's prey alive and feel nothing at all about it, and many other similar examples of cruelty exist in nature, many even eat their own species in special circumstances, despite that I don't consider any of them evil. Nothing short of a highly contagious virus that affects the brain and makes us more emphatic (with no other side effect) would break the cycle, but that's just sci-fi talk.

wolfram74 1y ago
What, did you read Adrian Tchaikovsky's Children of Time recently?
- AmbroseBierce 1y ago
  No idea who that is, but it's not particularly challenging to realize evolution doesn't overall favor empathy -even if it played some role-, sometimes it's the full opposite, sometimes is punished ("no good deed goes unpunished"), firemen are the most prone to burns, the equivalent it's true for many other altruistic endeavors, including rare occasional ones unlike firemen. It's also not particularly challenging to see society lacks any intrinsic defence from the most ruthless and greedy from advancing in any given power structure inside of it, it's a long term damage so it's abstracted away while more immediate issues take presedence, it's in our DNA to give too priority to immediate threats, while long term problems such as this don't make the top 10 (another example being climate change, etc)
codesnik 1y ago
I wonder if somebody already experiments on altering toxoplasmosis

ben_w 1y ago

Sadly, we will never run out of evil people regardless. For every evil old person today, there's a handful of evil younger people behind them, just because of demographics.

henriquenunez 1y ago

xi jinping and puting already said