In my experience the injections are very mild and easy to administer. As a kid I used to be afraid of becoming diabetic because I didn't think I'd be able to gi

In my experience the injections are very mild and easy to administer. As a kid I used to be afraid of becoming diabetic because I didn't think I'd be able to give myself insulin shots, but now I give myself a number of shots without issue. For most of these drugs, including lower-dose Skyrizi (like a "psoriasis only" dose), it's an auto-injector pen almost like an EpiPen where you just pinch the skin, press down, and a spring engages with minimal pain/effort. You don't even see the needle! And then my higher-dose Skyrizi is unique (as in, I've never seen any other biologics that do this, but it might become more popular) in that you actually stick a little plastic box to your leg/stomach for a few minutes that administers the dose for you. Again, you never have to see the needle, and there's a bit more sensation than a pen-style injection but it's mostly from the fact that the injection takes so long to complete (compared to a pen that takes 15-30 seconds from start to finish). Icing the area beforehand can help, too. I will also say there's truly never been a better time to be diagnosed with an autoimmune condition, given the quality and number of treatments available these days. For Crohn's and colitis in particular, if you catch it early enough and find a treatment that works for you, I believe it's possible to prevent the worst of the permanent damage so long as you remain in remission or mild-at-worst inflammation. Compare that to twenty years ago when there were only a few treatment options, which made it much harder to get in remission, which increased your odds of needing surgery or similar.