> Heart disease progresses over decades <...> You don't want to wait til you're 18 months out from a heart attack to do anything. I don't think this is good adv

> Heart disease progresses over decades <...> You don't want to wait til you're 18 months out from a heart attack to do anything. I don't think this is good advice Correct. The idea is commonly referred to as "LDL-C Burden" https://jamanetwork.com/journals/jamacardiology/fullarticle/2784038 https://jamanetwork.com/journals/jamacardiology/fullarticle/... > no solid evidence it can be reversed We do see good evidence of soft-plaque regression with very low levels of LDL-C, generally in patients undergoing high dose statin therapy or combo therapy. https://www.jacc.org/doi/10.1016/j.jacc.2021.10.035 https://www.jacc.org/doi/10.1016/j.jacc.2021.10.035 https://jamanetwork.com/journals/jama/fullarticle/2584184 https://jamanetwork.com/journals/jama/fullarticle/2584184 https://pmc.ncbi.nlm.nih.gov/articles/PMC7644491/ https://pmc.ncbi.nlm.nih.gov/articles/PMC7644491/ We don't have any real evidence of effective/widely-applicable treatments to reduce calcified plaque, though.