MR studies rule out the idea that inflammation is the sole causal factor, and we have a lot of them. We have MVMR studies that look at multiple variables http

MR studies rule out the idea that inflammation is the sole causal factor, and we have a lot of them. We have MVMR studies that look at multiple variables https://journals.plos.org/plosmedicine/article%3Fid%3D10.1371/journal.pmed.1003062 https://journals.plos.org/plosmedicine/article%3Fid%3D10.137... https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(21)00086-6/fulltext https://www.thelancet.com/journals/lanhl/article/PIIS2666-75... Some MR looking specifically at CRP actually dispute the idea of a causal link altogether https://www.bmj.com/content/342/bmj.d548 https://www.bmj.com/content/342/bmj.d548 https://www.ahajournals.org/doi/10.1161/01.atv.0000258869.48076.14 https://www.ahajournals.org/doi/10.1161/01.atv.0000258869.48... Factorial MR show strong evidence that the risk is additive, in the case of these that look at atherogenic particles and IL-6 signaling https://www.ahajournals.org/doi/10.1161/JAHA.121.023277 https://www.ahajournals.org/doi/10.1161/JAHA.121.023277 MR looking at specific genes that reduce LDL-C through a variety of mechanisms, including some that lower inflammation, show basically identical reduction of risk per LDL-C lowered. https://pubmed.ncbi.nlm.nih.gov/25770315/ https://pubmed.ncbi.nlm.nih.gov/25770315/ https://www.nejm.org/doi/full/10.1056/NEJMoa1604304 https://www.nejm.org/doi/full/10.1056/NEJMoa1604304