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Statins are generally administered after decades of exposure to high cholesterol/ApoB. Decades of plaque accumulation doesn't just go away when you lower your
by hombre_fatal 1y ago
Statins are generally administered after decades of exposure to high cholesterol/ApoB.
Decades of plaque accumulation doesn't just go away when you lower your cholesterol.
The question is if people who keep their cholesterol/ApoB low (e.g. Mendellian randomization) have better health outcomes, and the evidence is clear. Lifelong exposure to cholesterol/ApoB mediates atherosclerosis.
- PantaloonFlames 1y ago> Lifelong exposure to cholesterol/ApoB mediates atherosclerosis I would normally interpret that to mean, lifelong elevated levels of cholesterol/ApoB _decreases_ atherosclerosis. Is that what you meant?
- deleted 1y ago[deleted]
- mikeyouse 1y agoIn medicine, “mediates” is mostly synonymous with “facilitates”. So ‘lifelong exposure to cholesterol facilitates atherosclerosis’ - mediates is a bit softer since health changes often involve multiple pathways and can be impacted by many other processes.