I don’t disagree with your point, but I just would like to point out that there are over 100 known post-transcriptional modified RNA bases [1]. In fact, tRNA ar

I don’t disagree with your point, but I just would like to point out that there are over 100 known post-transcriptional modified RNA bases [1]. In fact, tRNA are more modified bases than canonical if taken as a whole. AND! the ribosome can’t function without all of its modifications. If I were to put money toward “targeting an RNA to make a drug” rRNA is where I’d aim… Source: PhD in RNA modifications [1] https://pmc.ncbi.nlm.nih.gov/articles/PMC9073955/ https://pmc.ncbi.nlm.nih.gov/articles/PMC9073955/