The association between pathogens and cancer is under-appreciated, mostly due to limitations in detection methods. For instance, it is not uncommon for cancer

The association between pathogens and cancer is under-appreciated, mostly due to limitations in detection methods. For instance, it is not uncommon for cancer studies to design assays around non-oncogenic strains, or for assays to use primer sequences with binding sites mismatched to a large number of NCBI GenBank genomes. Another example: studies relying on The Cancer Genome Atlas (TCGA), which is a rich database for cancer investigations. However, the TCGA made a deliberate tradeoff to standardize quantification of eukaryotic coding transcripts but at the cost of excluding non-poly(A) transcripts like EBER1/2 and other viral non-coding RNAs -- thus potentially understating viral presence. Enjoy the rabbit hole. :)