3 ms·

> The $1-trillion cuts to Medicaid No, that is false. The state Democratic parties are going to cut far, far more. > the Trump administration You just knew t

> The $1-trillion cuts to Medicaid No, that is false. The state Democratic parties are going to cut far, far more. > the Trump administration You just knew that was coming. My previous statement is unmentioned of course, despite the obviousness of it. That's how propaganda works. Roughly 6-7% of this article. > The OBBBA language that cut and restructured Medicaid included explicit exemptions for people classified as "medically frail", which in federal Medicaid law covers people with physical, intellectual, and developmental disabilities. Just kidding, we know full well that's not in this article. > biology ... genes For a article on a medical topic, this article says almost nothing about the underlying biology of autism, at least nothing more than an American Eagle ad. It is really all about that closing, to keep the fire going. Propaganda. Sorry I couldn't get to this article sooner, I was editing Wikipedia on healthcare topics, pretty much fighting against everything this article is about.

esbranson 1y ago
I'm going to spend about 5 minutes and maybe do a better job at science than this article: Autisms are biologically caused by disruptions in early brain development that alter how synapses are formed, pruned, and regulated, producing imbalances in excitatory and inhibitory signaling across neural circuits. Most cases trace to combinations of genetic variants—some rare, high-impact mutations affecting synaptic scaffolding (e.g., postsynaptic density proteins), neuronal excitability (ion channels), chromatin remodeling, or transcriptional control, and many common variants with smaller effects—while prenatal factors such as maternal immune activation, teratogens, or perinatal stress can act as modifiers. These converging influences disturb synaptic wiring, circuit dynamics, developmental timing, and gene-expression programs, leading to atypical brain connectivity: often locally hyperconnected yet underintegrated across distant regions. This altered network balance underlies the sensory, communicative, and behavioral traits recognized as the autism spectrum. Synapse Formation and Balance: – Faulty assembly and regulation of excitatory and inhibitory synapses. – Leads to unstable network tuning, “noisy” signaling, and altered local vs. global connectivity. Neuronal Firing and Circuit Dynamics: – Changes in ion channel function distort how neurons spike and synchronize. – Affects rhythmic activity (oscillations) important for sensory integration and social cognition. Neurodevelopmental Timing: – Mistimed growth, migration, and pruning of neurons. – Results in atypical wiring patterns: often hyperconnected locally but underconnected long-range. Gene Expression Control: – Master regulators fail to coordinate large developmental programs. – Produces ripple effects across hundreds of downstream pathways, compounding small errors.

esbranson 1y ago

I'm going to spend about 5 minutes and maybe do a better job at science than this article: Autisms are biologically caused by disruptions in early brain development that alter how synapses are formed, pruned, and regulated, producing imbalances in excitatory and inhibitory signaling across neural circuits. Most cases trace to combinations of genetic variants—some rare, high-impact mutations affecting synaptic scaffolding (e.g., postsynaptic density proteins), neuronal excitability (ion channels), chromatin remodeling, or transcriptional control, and many common variants with smaller effects—while prenatal factors such as maternal immune activation, teratogens, or perinatal stress can act as modifiers. These converging influences disturb synaptic wiring, circuit dynamics, developmental timing, and gene-expression programs, leading to atypical brain connectivity: often locally hyperconnected yet underintegrated across distant regions. This altered network balance underlies the sensory, communicative, and behavioral traits recognized as the autism spectrum. Synapse Formation and Balance: – Faulty assembly and regulation of excitatory and inhibitory synapses. – Leads to unstable network tuning, “noisy” signaling, and altered local vs. global connectivity. Neuronal Firing and Circuit Dynamics: – Changes in ion channel function distort how neurons spike and synchronize. – Affects rhythmic activity (oscillations) important for sensory integration and social cognition. Neurodevelopmental Timing: – Mistimed growth, migration, and pruning of neurons. – Results in atypical wiring patterns: often hyperconnected locally but underconnected long-range. Gene Expression Control: – Master regulators fail to coordinate large developmental programs. – Produces ripple effects across hundreds of downstream pathways, compounding small errors.