5 ms·

Type 2, they need to solve type 2.

by m3kw9 1y ago

kingkawn 1y ago
Nobody had thought of this wow
- bentt 1y ago
  We were here, at the moment of inspiration
mezeek 1y ago
isn't that what GLP1s are for (before you get full blown type 2)
- javchz 1y ago
  Yes, but even lifestyle changes (like a diet low in glycemic load and building muscle) can help reduce many of the harmful effects of type 2 diabetes, even sending it into remission for some people in early stages. Type 1 is a different story. It’s the lack of natural insulin production (due to a damaged pancreas, autoimmune or other causes), basically the opposite problem to type 2, and no amount of lifestyle changes will replace of need of insulin doses.
- kulahan 1y ago
  I just want to make clear what the other commenter said: type 2 is completely reversible in its early stages. Lose weight, eat a more healthy diet, and you should see your body return to normal. Unfortunately, there's a serious time limit on this news, as the disease does permanently damage your cells, but in a way that's not terrible. It's probably easier to be shocked by a diagnosis into a lifestyle change than to find out now and undo 30 years of living with daily insulin injections anyways.
moi2388 1y ago
[flagged]
- UI_at_80x24 1y ago
  I know you put the caveat "mostly" in here but it's important to state that this is not always true. I was diagnosed with T2 a couple of years ago. During that time I was cycling 25 miles a day. After the diagnoses I completely eliminated all carbs from my diet. My blood sugar was still not under control. My fasting blood sugar (first thing in the morning, and 18hrs of fasting) was the highest point of the day. (14-18 mmol/L) I fasted (water only) for 1 week. no difference. I was on a bunch of medication, none of it helped. It wasn't until I started taking a GLP-1 drug that my sugar came under control. So medication (ozempic) was critical to me getting my blood sugar under control. Diet didn't fix it. Exercise didn't help. I've lost ~90lbs since then. I'd probably have died/gone into a coma if not for GLP-based drugs. My anecdote does not contradict wide-spread science and medically derived knowledge. But it should help temper the fat and diet shaming that exists in society.
  - fhdkweig 1y ago
    If you lost 90 lbs, you must have been at least 90 lbs overweight. That isn't a little bit of fat. That is a lot of fat. And it takes a lifetime to put on that much fat. You can't really claim that you had proper exercise and diet before you started taking medications. I have seen many episodes of My 600 LB Life and similar shows where the clients and their caretakers swear on their mother's graves that they even eat at all, but that isn't how reality and physics work. Don't misunderstand, I'm glad they made the GLP-1 drugs, but still, they have for years been reversing Type 2 diabetes through exercise a diet.
    - ToucanLoucan 1y ago
      Calories in/out is the only reliable way (short of surgery or drugs anyway) to reliably change the size of your body in either direction. Genetics, where you are on the planet, hormones, and your average activity levels tweak things but this remains fundamentally true: If you eat in a calorie deficit, you will lose weight. If you eat in a calorie surplus, you will gain weight. It's not hateful, it's math. If you have a hard time getting your intake down due to life circumstances, addictions, stress, whatever, you have my utmost sympathies and I would do anything I could to help, but I'm not going to bullshit you. If you want to weigh less, you must, over a long period of time, take in fewer calories than you burn in a day. That is how you lose weight in the most nuts-and-bolts way there is.
snarf21 1y ago
There have been a lot of advancements on this front too. One promising technique is duodenum resurfacing (DMR). This helps reset some of the insulin sensitivity issues. The one problem we have is that this is a one time low risk procedure compared to selling insulin or GLP-1. Like all of our problems in healthcare, we have a major misalignment in incentives.
- PicassoCTs 1y ago
  [dead]
toomuchtodo 1y ago
If GLP-1 Drugs Are Good for Everything, Should We All Be on Them? - https://news.ycombinator.com/item?id=44830685 https://news.ycombinator.com/item?id=44830685 - August 2025
CyberDildonics 1y ago
If you treat sugar as an addiction you can solve it yourself.

Type 2, they need to solve type 2.

by m3kw9 1y ago

Type 2, they need to solve type 2.

kingkawn 1y ago

Nobody had thought of this wow

bentt 1y ago
We were here, at the moment of inspiration

mezeek 1y ago

isn't that what GLP1s are for (before you get full blown type 2)

javchz 1y ago
Yes, but even lifestyle changes (like a diet low in glycemic load and building muscle) can help reduce many of the harmful effects of type 2 diabetes, even sending it into remission for some people in early stages. Type 1 is a different story. It’s the lack of natural insulin production (due to a damaged pancreas, autoimmune or other causes), basically the opposite problem to type 2, and no amount of lifestyle changes will replace of need of insulin doses.
kulahan 1y ago
I just want to make clear what the other commenter said: type 2 is completely reversible in its early stages. Lose weight, eat a more healthy diet, and you should see your body return to normal. Unfortunately, there's a serious time limit on this news, as the disease does permanently damage your cells, but in a way that's not terrible. It's probably easier to be shocked by a diagnosis into a lifestyle change than to find out now and undo 30 years of living with daily insulin injections anyways.

moi2388 1y ago

[flagged]

UI_at_80x24 1y ago
I know you put the caveat "mostly" in here but it's important to state that this is not always true. I was diagnosed with T2 a couple of years ago. During that time I was cycling 25 miles a day. After the diagnoses I completely eliminated all carbs from my diet. My blood sugar was still not under control. My fasting blood sugar (first thing in the morning, and 18hrs of fasting) was the highest point of the day. (14-18 mmol/L) I fasted (water only) for 1 week. no difference. I was on a bunch of medication, none of it helped. It wasn't until I started taking a GLP-1 drug that my sugar came under control. So medication (ozempic) was critical to me getting my blood sugar under control. Diet didn't fix it. Exercise didn't help. I've lost ~90lbs since then. I'd probably have died/gone into a coma if not for GLP-based drugs. My anecdote does not contradict wide-spread science and medically derived knowledge. But it should help temper the fat and diet shaming that exists in society.
- fhdkweig 1y ago
  If you lost 90 lbs, you must have been at least 90 lbs overweight. That isn't a little bit of fat. That is a lot of fat. And it takes a lifetime to put on that much fat. You can't really claim that you had proper exercise and diet before you started taking medications. I have seen many episodes of My 600 LB Life and similar shows where the clients and their caretakers swear on their mother's graves that they even eat at all, but that isn't how reality and physics work. Don't misunderstand, I'm glad they made the GLP-1 drugs, but still, they have for years been reversing Type 2 diabetes through exercise a diet.
  - ToucanLoucan 1y ago
    Calories in/out is the only reliable way (short of surgery or drugs anyway) to reliably change the size of your body in either direction. Genetics, where you are on the planet, hormones, and your average activity levels tweak things but this remains fundamentally true: If you eat in a calorie deficit, you will lose weight. If you eat in a calorie surplus, you will gain weight. It's not hateful, it's math. If you have a hard time getting your intake down due to life circumstances, addictions, stress, whatever, you have my utmost sympathies and I would do anything I could to help, but I'm not going to bullshit you. If you want to weigh less, you must, over a long period of time, take in fewer calories than you burn in a day. That is how you lose weight in the most nuts-and-bolts way there is.

snarf21 1y ago

There have been a lot of advancements on this front too. One promising technique is duodenum resurfacing (DMR). This helps reset some of the insulin sensitivity issues. The one problem we have is that this is a one time low risk procedure compared to selling insulin or GLP-1. Like all of our problems in healthcare, we have a major misalignment in incentives.

PicassoCTs 1y ago
[dead]

toomuchtodo 1y ago

If GLP-1 Drugs Are Good for Everything, Should We All Be on Them? - https://news.ycombinator.com/item?id=44830685 https://news.ycombinator.com/item?id=44830685 - August 2025

CyberDildonics 1y ago

If you treat sugar as an addiction you can solve it yourself.