As someone hoping to enter a systems metabolomics program next year, let me simplify your statement: If you do this, you're messing with high-order, nonlinear

As someone hoping to enter a systems metabolomics program next year, let me simplify your statement: If you do this, you're messing with high-order, nonlinear dynamics. Does anyone really trust themselves to dose that properly? They had better be a trained medicinal chemist with great skill at solving PDEs. I also doubt the average enthusiast is set up to run HPLC to measure and model various critical metabolite concentrations and their change over time.