> Until you have a controlled study on pregnant women I wouldn’t look for a prospective randomized controlled trial of this anytime soon. Hard to imagine an IR

> Until you have a controlled study on pregnant women I wouldn’t look for a prospective randomized controlled trial of this anytime soon. Hard to imagine an IRB approving such a study. Observational studies do suggest a small but statistically significant association between acetaminophen use in pregnancy and ASD, but the relative risk increase is small, because both the effect size and baseline risk are small.