3 ms·

The craziest part about this is that it's true, when Tylenol was approved it was studied for acute toxicity, but at the time we didn't know how to study for lon

The craziest part about this is that it's true, when Tylenol was approved it was studied for acute toxicity, but at the time we didn't know how to study for long term neurological toxicity.

bigyabai 1y ago
Do we have the data that confirms this? It may well be true, but still not the leading cause of autism.
- rogerkirkness 1y ago
  Definitely not the leading cause of autism, definitely a contributing factor to the complicated generic expression cascade that can lead to autism [1]. "We identified 46 studies for inclusion in our analysis. Of these, 27 studies reported positive associations (significant links to NDDs), 9 showed null associations (no significant link), and 4 indicated negative associations (protective effects). Higher-quality studies were more likely to show positive associations. Overall, the majority of the studies reported positive associations of prenatal acetaminophen use with ADHD, ASD, or NDDs in offspring, with risk-of-bias and strength-of-evidence ratings informing the overall synthesis." Added link for lazy people who don't have Google. [1] https://ehjournal.biomedcentral.com/articles/10.1186/s12940-025-01208-0 https://ehjournal.biomedcentral.com/articles/10.1186/s12940-...
  - jleyank 1y ago
    “Definitely”. Ok, citations?
    - rogerkirkness 1y ago
      Why don't you type 'paracetamol autism' into Google Scholar, too hard for you? "We identified 46 studies for inclusion in our analysis. Of these, 27 studies reported positive associations (significant links to NDDs), 9 showed null associations (no significant link), and 4 indicated negative associations (protective effects). Higher-quality studies were more likely to show positive associations. Overall, the majority of the studies reported positive associations of prenatal acetaminophen use with ADHD, ASD, or NDDs in offspring, with risk-of-bias and strength-of-evidence ratings informing the overall synthesis." [1]: https://ehjournal.biomedcentral.com/articles/10.1186/s12940-025-01208-0 https://ehjournal.biomedcentral.com/articles/10.1186/s12940-...
      - tomhow 1y ago
        > Why don't you type 'paracetamol autism' into Google Scholar, too hard for you? Please avoid swipes like this on HN.
        jleyank 1y ago
        Google is often like drinking from a firehouse and my skill set doesn’t include bio- or medicinal chemistry. Hard to evaluate the output w/o the proper skills.

The craziest part about this is that it's true, when Tylenol was approved it was studied for acute toxicity, but at the time we didn't know how to study for long term neurological toxicity.

bigyabai 1y ago

Do we have the data that confirms this? It may well be true, but still not the leading cause of autism.

rogerkirkness 1y ago
Definitely not the leading cause of autism, definitely a contributing factor to the complicated generic expression cascade that can lead to autism [1]. "We identified 46 studies for inclusion in our analysis. Of these, 27 studies reported positive associations (significant links to NDDs), 9 showed null associations (no significant link), and 4 indicated negative associations (protective effects). Higher-quality studies were more likely to show positive associations. Overall, the majority of the studies reported positive associations of prenatal acetaminophen use with ADHD, ASD, or NDDs in offspring, with risk-of-bias and strength-of-evidence ratings informing the overall synthesis." Added link for lazy people who don't have Google. [1] https://ehjournal.biomedcentral.com/articles/10.1186/s12940-025-01208-0 https://ehjournal.biomedcentral.com/articles/10.1186/s12940-...
- jleyank 1y ago
  “Definitely”. Ok, citations?
  - rogerkirkness 1y ago
    Why don't you type 'paracetamol autism' into Google Scholar, too hard for you? "We identified 46 studies for inclusion in our analysis. Of these, 27 studies reported positive associations (significant links to NDDs), 9 showed null associations (no significant link), and 4 indicated negative associations (protective effects). Higher-quality studies were more likely to show positive associations. Overall, the majority of the studies reported positive associations of prenatal acetaminophen use with ADHD, ASD, or NDDs in offspring, with risk-of-bias and strength-of-evidence ratings informing the overall synthesis." [1]: https://ehjournal.biomedcentral.com/articles/10.1186/s12940-025-01208-0 https://ehjournal.biomedcentral.com/articles/10.1186/s12940-...
    - tomhow 1y ago
      > Why don't you type 'paracetamol autism' into Google Scholar, too hard for you? Please avoid swipes like this on HN.
      - jleyank 1y ago
        Google is often like drinking from a firehouse and my skill set doesn’t include bio- or medicinal chemistry. Hard to evaluate the output w/o the proper skills.