There is a thriving cult following of 2d animation on Youtube, but like many things this has a fractured audience, no longer a unified pop culture. Sparklehorse

There is a thriving cult following of 2d animation on Youtube, but like many things this has a fractured audience, no longer a unified pop culture. Sparklehorse has Hazbin Hotel and Helluva Boss. Glitch Productions has The Amazing Digital Circus which is retro-3d, but seems to also be producing the former Disney Owl House creator to make Knights of Guinevere.