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Thinks : "What is an inactive form of a B-vitamin?". Some examples: B1 - Thiamin [Inactive] vs Thiamine Diphosphate [Active]. B2 - Flavin Mononucleotide (FMN)

Thinks : "What is an inactive form of a B-vitamin?". Some examples: B1 - Thiamin [Inactive] vs Thiamine Diphosphate [Active]. B2 - Flavin Mononucleotide (FMN) vs Flavin Adenine Dinucleotide (FAD). B12 - Cyanocobalamine vs Methylcobalamin. Interesting. So the idea is that an excess of (say) FMN would block conversion to FAD?

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gilleain 1y ago
Hmmm, even a small amount of rabbit-hole diving turns up some curious statements around this : > Cyanocobalamin is also the most common form of vitamin B12 found in supplements. It is named because it contains a cyanide molecule. The amount of cyanide found in cyanocobalamin supplements tends to be small, but the body still has to do extra “work” to remove and eliminate the cyanide molecule. If your liver is already overworked, this added step can make activating this nutrient more challenging. I'm sceptical that the extra 'work' here to convert CNCbl to MeCbl is significantly taxing for the liver. B12 is needed in very small amounts ("the upper limit of absorption per single oral dose is about 1.5 μg" - wikipedia). More on this: https://pmc.ncbi.nlm.nih.gov/articles/PMC5312744/ https://pmc.ncbi.nlm.nih.gov/articles/PMC5312744/ > Numerous studies and reviews of B12 metabolism have shown that CNCbl, MeCbl, OHCbl, and AdCbl are reduced to the core cobalamin molecule inside the cytosol. It is important to note that the ligands specific to the ingested B12 form—methyl and adenosyl—are removed during that process and not used inside cells during the conversion of cobalamin to the 2 active forms of B12 Certainly that review suggests that taking one of the bioavailable forms (MeCbl, OHCbl, AdCbl) is _better_ than the usual CNCbl one, but I see no mention of CNCbl being more 'taxing' in some sense.
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gilleain 1y ago

Hmmm, even a small amount of rabbit-hole diving turns up some curious statements around this : > Cyanocobalamin is also the most common form of vitamin B12 found in supplements. It is named because it contains a cyanide molecule. The amount of cyanide found in cyanocobalamin supplements tends to be small, but the body still has to do extra “work” to remove and eliminate the cyanide molecule. If your liver is already overworked, this added step can make activating this nutrient more challenging. I'm sceptical that the extra 'work' here to convert CNCbl to MeCbl is significantly taxing for the liver. B12 is needed in very small amounts ("the upper limit of absorption per single oral dose is about 1.5 μg" - wikipedia). More on this: https://pmc.ncbi.nlm.nih.gov/articles/PMC5312744/ https://pmc.ncbi.nlm.nih.gov/articles/PMC5312744/ > Numerous studies and reviews of B12 metabolism have shown that CNCbl, MeCbl, OHCbl, and AdCbl are reduced to the core cobalamin molecule inside the cytosol. It is important to note that the ligands specific to the ingested B12 form—methyl and adenosyl—are removed during that process and not used inside cells during the conversion of cobalamin to the 2 active forms of B12 Certainly that review suggests that taking one of the bioavailable forms (MeCbl, OHCbl, AdCbl) is _better_ than the usual CNCbl one, but I see no mention of CNCbl being more 'taxing' in some sense.

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