That would be neat. But sadly thermodynamics gets in the way. I did see a minipc where the graphics card was being cooled by a liquid cooler that had the cooler

That would be neat. But sadly thermodynamics gets in the way. I did see a minipc where the graphics card was being cooled by a liquid cooler that had the cooler unit under the desk but its not really a "mini" pc at that point, its a disaggregated pc with separate compute and cooling :-).