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There is mounting talk of a link between Paracetamol/Acetaminophen/Tylenol and autism. Some links: https://hsph.harvard.edu/news/using-acetaminophen-during-pr

There is mounting talk of a link between Paracetamol/Acetaminophen/Tylenol and autism. Some links: https://hsph.harvard.edu/news/using-acetaminophen-during-pregnancy-may-increase-childrens-autism-and-adhd-risk/ https://hsph.harvard.edu/news/using-acetaminophen-during-pre... https://jennifermargulis.substack.com/p/why-this-doctor-is-convinced-he-knows https://jennifermargulis.substack.com/p/why-this-doctor-is-c...

zoeysmithe 1y ago
It tends to be poor scholarship imho. Autistic moms are more likely to have chronic illness, sensory issues, auto immune issues, etc thus are more likely to be taking medications. In the end, the autistic mom just passes her autistic genes to the baby.
sigpwned 1y ago
A study published in JAMA in 2024 concluded that there is no evidence for that claim (https://jamanetwork.com/journals/jama/fullarticle/2817406 https://jamanetwork.com/journals/jama/fullarticle/2817406): Question: Does acetaminophen use during pregnancy increase children’s risk of neurodevelopmental disorders? Findings: In this population-based study, models without sibling controls identified marginally increased risks of autism and attention-deficit/hyperactivity disorder (ADHD) associated with acetaminophen use during pregnancy. However, analyses of matched full sibling pairs found no evidence of increased risk of autism (hazard ratio, 0.98), ADHD (hazard ratio, 0.98), or intellectual disability (hazard ratio, 1.01) associated with acetaminophen use. Meaning: Acetaminophen use during pregnancy was not associated with children’s risk of autism, ADHD, or intellectual disability in sibling control analyses. This suggests that associations observed in other models may have been attributable to confounding.
- deleted 1y ago
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- WorkerBee28474 1y ago
  The 1 study you linked does not disprove the newer 46-study analysis that I linked. Quoting from it: "We identified 46 studies for inclusion in our analysis. Of these, 27 studies reported positive associations (significant links to NDDs), 9 showed null associations (no significant link), and 4 indicated negative associations (protective effects). Higher-quality studies were more likely to show positive associations."

zoeysmithe 1y ago

It tends to be poor scholarship imho. Autistic moms are more likely to have chronic illness, sensory issues, auto immune issues, etc thus are more likely to be taking medications. In the end, the autistic mom just passes her autistic genes to the baby.

sigpwned 1y ago

A study published in JAMA in 2024 concluded that there is no evidence for that claim (https://jamanetwork.com/journals/jama/fullarticle/2817406 https://jamanetwork.com/journals/jama/fullarticle/2817406): Question: Does acetaminophen use during pregnancy increase children’s risk of neurodevelopmental disorders? Findings: In this population-based study, models without sibling controls identified marginally increased risks of autism and attention-deficit/hyperactivity disorder (ADHD) associated with acetaminophen use during pregnancy. However, analyses of matched full sibling pairs found no evidence of increased risk of autism (hazard ratio, 0.98), ADHD (hazard ratio, 0.98), or intellectual disability (hazard ratio, 1.01) associated with acetaminophen use. Meaning: Acetaminophen use during pregnancy was not associated with children’s risk of autism, ADHD, or intellectual disability in sibling control analyses. This suggests that associations observed in other models may have been attributable to confounding.

deleted 1y ago
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WorkerBee28474 1y ago
The 1 study you linked does not disprove the newer 46-study analysis that I linked. Quoting from it: "We identified 46 studies for inclusion in our analysis. Of these, 27 studies reported positive associations (significant links to NDDs), 9 showed null associations (no significant link), and 4 indicated negative associations (protective effects). Higher-quality studies were more likely to show positive associations."