4 ms·
Serious question: With all the advancements in mice medicine, are we theoretically able to create immortal mice?
by punkpeye 1y ago
Serious question: With all the advancements in mice medicine, are we theoretically able to create immortal mice?
- Nevermark 1y agoI think if we were, we would have immortal mice.
- DrewADesign 1y agoHaving lived in some of the apartments I've lived in, I'm not sure that we don't.
- lblume 1y agoAre you sure the mice don't change?
- DrewADesign 1y agoOne older balding mouse would hold court in the pantry periodically-- he had a little gold ring that he made the other mice kiss before they conferred with him about various happenings around the apartment. I'm pretty sure he was in it for the long haul.
- wiseowise 1y agoYou kill one fucker, twenty show up to its funeral.
- deleted 1y ago[deleted]
- kulahan 1y agoNo. Originally we sketched out 9 hallmarks of aging, and it has since increased to twelve. We don’t have a full picture of immortality yet, let alone conquering it.
- lawlessone 1y agoEven if we can't do it biologically i wonder how much we could extend it with artificial organs? Most deaths seem to be cardiovascular, heart disease, stroke, then followed by cancer.
- raluk 1y agoGiven that you die, when one vital organ dies it will eventaully hapen in this way or another. I read somwhere and that stuck in my brain, that maxmimal logevity for humans is estimated to be approximetly 125 years.
- Windchaser 1y ago>> I read somwhere and that stuck in my brain, that maxmimal logevity for humans is estimated to be approximetly 125 years. Oh, that's just derived from old theology. Genesis 6:3, 'Then the LORD said, “My Spirit will not contend with humans forever, for they are mortal; their days will be a hundred and twenty years.”' This kinda got spread throughout the zeitgeist long ago as a "maximal lifespan", but the reality is that only 3 in 10,000 even make it to 100. There's no hard cutoff, but functionally essentially no one gets to 110. Scientifically, there's no hard reason we couldn't increase our lifespans indefinitely, but we've got a lot of work to do before we'll be able to get a reasonable number of people up to 125.
- binary132 1y agoThat doesn’t sound like you’re disagreeing with gp.
- sockaddr 1y agoIf we count a permanently inflamed organic blob in roughly the shape of a mouse covered by surgical scars constantly pumped with anti-rejection drugs and hooked up to a blood filter we could probably make the mouse immortal now. It might not enjoy living though.
- deadbabe 1y agoThat would be very dangerous and possibly the plot of some hard sci-fi thriller. If immortal mice were to somehow escape the lab and breed in the wild we could rapidly end up with massive populations of mice that never die of aging, ultimately collapsing entire ecosystems and food chains, leading to the end of humanity.
- lblume 1y ago1. Of course they should be sterilized. 2. The most common causes of death for wild mice are predation, diseases, and starvation. Theoretically immortal mice have no chance in the real world if not very well-adapted to these conditions.
- 0cf8612b2e1e 1y agoIt’s also not hard to imagine that an immortal organism has higher metabolic needs. Meaning they are more prone to starvation and potentially less fit.
- prerok 1y agoMice? No, too many predators. Now, crows that would be a different matter. Already seen in the movie "Birds" ;)
- NooneAtAll3 1y agoeven focusing on age-related death, you assume that such treatment is one-and-done deal instead of continuous pharmaceutical life support
- narag 1y agoSo they won't be immortal for too long.
- NooneAtAll3 1y agoactive support do be like that
- pupppet 1y agoTime for a The Secret of NIMH rewatch.
- narrator 1y agoThe robust mouse rejuvenation study is ongoing. Basically they took a lot of mice and threw the kitchen sink of promising age reversing therapies at them: https://www.levf.org/projects/robust-mouse-rejuvenation-study-1 https://www.levf.org/projects/robust-mouse-rejuvenation-stud... Just off the top of my head, I think the longest they ever got a mouse to live in a study was the C-60 study where they wanted to test whether it was toxic and the mouse lived almost twice their normal lifespan. This paper has been cited over 300 times, so it's not like people haven't taken notice of it. There are a few supplement companies selling c-60 olive oil too: https://www.sciencedirect.com/science/article/abs/pii/S0142961212003237 https://www.sciencedirect.com/science/article/abs/pii/S01429... "Here we show that oral administration of C60 dissolved in olive oil (0.8 mg/ml) at reiterated doses (1.7 mg/kg of body weight) to rats not only does not entail chronic toxicity but it almost doubles their lifespan"
- _0ffh 1y agoBearing in mind that the C60 study (from 2012) has never been succesfully replicated since, despite multiple attempts.
- punkpeye 1y agoDid we manage to accidentally make something live twice as long and then abandon efforts to replicate the results?
- readthenotes1 1y agoOr were there other problems in the data?