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What I mean is that the Hayflick limit is a concept from the laboratory; it applies to cells that divide quickly, like skin cells, but it has limited practical
by JPLeRouzic 1y ago
What I mean is that the Hayflick limit is a concept from the laboratory; it applies to cells that divide quickly, like skin cells, but it has limited practical use for strategies aimed at extending an animal's lifespan, because as the animal or human ages, it will lose neurons and muscle strength (including heart muscle).
In other words, 100% of humans relying only or mainly on telomere repair will be faced with Alzheimer’s, Parkinson’s, and/or ALS, as well as cardiovascular diseases, before they reach 100 years old.
- nikolay 1y agoI thought we're past the times when we thought cartilage, neurons, and other tissues cannot regenerate. Didn't we, for example, find that BDNF activators can trigger neurogenesis?
- JPLeRouzic 1y agoHow do you create a well-connected motor neuron with a 3-foot or one-meter-long axon? Or brain neurons that are highly connected to other areas? I would appreciate any pointers to a scientific article that describes this.
- nikolay 1y agoPeripheral neurons can regenerate [0]. Heart muscle also can repair through other factors [1]. [0]: https://pmc.ncbi.nlm.nih.gov/articles/PMC6336700/ https://pmc.ncbi.nlm.nih.gov/articles/PMC6336700/ [1]: https://www.sciencealert.com/new-study-reveals-more-about-how-the-heart-repairs-itself-after-a-heart-attack https://www.sciencealert.com/new-study-reveals-more-about-ho...