Can anyone in the field summarize the road map and how close we might be to using mRNA-based nanoparticles as a system–rewriting strategy that may point toward

Can anyone in the field summarize the road map and how close we might be to using mRNA-based nanoparticles as a system–rewriting strategy that may point toward a true cure? I get that results exist only in preclinical animal studies (mice), with no published human trials yet. So would the next milestone be for small-scale human safety trials, similar to the early testing phases of the COVID mRNA vaccines? If so, could success be as quick as with the COVID mRNA vaccines, given how widespread allergies are becoming?