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I apologize about the typo, but it's true that cells don't divine without a (Hayflick) limit due to telomere shortening. Excessive autophagy is detrimental. The

I apologize about the typo, but it's true that cells don't divine without a (Hayflick) limit due to telomere shortening. Excessive autophagy is detrimental. The best strategy is to prevent cells from becoming senescent.

JPLeRouzic 1y ago
No worries! Not all cells divide (neurons and some muscle cells don't divide); some cells divide very slowly. And in some cases telomeres may be repaired but this increases the risk of cancer [0] https://biologyinsights.com/what-is-telomere-repair-and-is-it-safe/ https://biologyinsights.com/what-is-telomere-repair-and-is-i...
- nikolay 1y ago
  I'm fully aware of cancer risks with substances such as astalagus extract, but maybe telomerase activators can be combined with anti-cancer strategies such as fasting, etc.
  - JPLeRouzic 1y ago
    What I mean is that the Hayflick limit is a concept from the laboratory; it applies to cells that divide quickly, like skin cells, but it has limited practical use for strategies aimed at extending an animal's lifespan, because as the animal or human ages, it will lose neurons and muscle strength (including heart muscle). In other words, 100% of humans relying only or mainly on telomere repair will be faced with Alzheimer’s, Parkinson’s, and/or ALS, as well as cardiovascular diseases, before they reach 100 years old.
    - nikolay 1y ago
      I thought we're past the times when we thought cartilage, neurons, and other tissues cannot regenerate. Didn't we, for example, find that BDNF activators can trigger neurogenesis?
      - JPLeRouzic 1y ago
        How do you create a well-connected motor neuron with a 3-foot or one-meter-long axon? Or brain neurons that are highly connected to other areas? I would appreciate any pointers to a scientific article that describes this.
        nikolay 1y ago
        Peripheral neurons can regenerate [0]. Heart muscle also can repair through other factors [1]. [0]: https://pmc.ncbi.nlm.nih.gov/articles/PMC6336700/ https://pmc.ncbi.nlm.nih.gov/articles/PMC6336700/ [1]: https://www.sciencealert.com/new-study-reveals-more-about-how-the-heart-repairs-itself-after-a-heart-attack https://www.sciencealert.com/new-study-reveals-more-about-ho...

JPLeRouzic 1y ago

No worries! Not all cells divide (neurons and some muscle cells don't divide); some cells divide very slowly. And in some cases telomeres may be repaired but this increases the risk of cancer [0] https://biologyinsights.com/what-is-telomere-repair-and-is-it-safe/ https://biologyinsights.com/what-is-telomere-repair-and-is-i...

nikolay 1y ago
I'm fully aware of cancer risks with substances such as astalagus extract, but maybe telomerase activators can be combined with anti-cancer strategies such as fasting, etc.
- JPLeRouzic 1y ago
  What I mean is that the Hayflick limit is a concept from the laboratory; it applies to cells that divide quickly, like skin cells, but it has limited practical use for strategies aimed at extending an animal's lifespan, because as the animal or human ages, it will lose neurons and muscle strength (including heart muscle). In other words, 100% of humans relying only or mainly on telomere repair will be faced with Alzheimer’s, Parkinson’s, and/or ALS, as well as cardiovascular diseases, before they reach 100 years old.
  - nikolay 1y ago
    I thought we're past the times when we thought cartilage, neurons, and other tissues cannot regenerate. Didn't we, for example, find that BDNF activators can trigger neurogenesis?
    - JPLeRouzic 1y ago
      How do you create a well-connected motor neuron with a 3-foot or one-meter-long axon? Or brain neurons that are highly connected to other areas? I would appreciate any pointers to a scientific article that describes this.
      - nikolay 1y ago
        Peripheral neurons can regenerate [0]. Heart muscle also can repair through other factors [1]. [0]: https://pmc.ncbi.nlm.nih.gov/articles/PMC6336700/ https://pmc.ncbi.nlm.nih.gov/articles/PMC6336700/ [1]: https://www.sciencealert.com/new-study-reveals-more-about-how-the-heart-repairs-itself-after-a-heart-attack https://www.sciencealert.com/new-study-reveals-more-about-ho...