4 ms·
Be careful when reading such blogs: > Note that the dosage in the mouse experiments is quite high — 0.1% of the body weight every day, meaning about 2 ounces a
by pama 1y ago
Be careful when reading such blogs:
> Note that the dosage in the mouse experiments is quite high — 0.1% of the body weight every day, meaning about 2 ounces a day for me (70 kg).
Mouse and human metabolism are very different. A better starting estimate would be 5g/day, not 57g/day. I hope people dont accidentally overdose themselves because of lack of a pharmacology background.
- rscho 1y agoLack of pharmacology background doesn't seem like the biggest issue when extrapolating from mouse to human.
- andoando 1y agoI just learned this the other day, but its called allometric scaling. Definitely far off linear.
- A_D_E_P_T 1y agolol, that one was really a howler. You're spot on. But for the rest of the forum: The most commonly accepted mouse-to-human conversion is: (D)*(3/37) = H Where D = the mouse dose in mg/kg. H = human dose in mg/kg. So if a 25g mouse eats 0.1% of its bodyweight in taurine, that comes out to 1000mg/kg. It translates to 81mg/kg for a human. If you weigh 100kg, an equivalent daily dose for you is 8.1 grams/day. The rat equation is similar, but 6/37 rather than 3/37.
- avarun 1y agoIn plain English: scale by body weight then divide by 12.
- Aurornis 1y agoScaling mouse doses to human by body weight is a common rookie mistake. A better estimate for dose scaling uses body surface area. Even with that, inter-species differences don’t allow prevent extrapolation. Scaling by body weight leads to the common mistake of dismissing mouse studies because the casual observer does the match (by weight) and thinks the dose used was excessive. It’s such a basic topic in medicine and scientific research that I don’t trust anyone who scales by body weight.
- ac29 1y ago> Be careful when reading such blogs I followed a link to another blog post of theirs in which they go on a rant claiming there was a conspiracy to suppress chloroquine and ivermectin as COVID treatments. I dont think anyone should be taking health advice from this person
- rscho 1y agoAmusingly, this was a very common if not the most common stance on this very website some time ago. Surely, don't look for assistance on the internet regarding memory issues.