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From the conclusion paragraph: > Your primary life extension program is diet and exercise. Choose a diet that works for you. Stay slim. Considering heart dise
by cj 1y ago
From the conclusion paragraph:
> Your primary life extension program is diet and exercise. Choose a diet that works for you. Stay slim.
Considering heart disease is the #1 killer, doing whatever you can to not die from heart disease is the best place for most people to start.
Even in 2025, diet and exercise are still king.
- adamgordonbell 1y agoAlso this: > The best reason to take multiple life extension supplements is to hedge our bets, because we really don’t know which of them are effective in humans. And earlier: > Personally, I take large doses of rapamycin 2 days a week, 8 weeks per year. For personalized recommendations, you can consult your favorite life extension doc.
- cactusplant7374 1y agoRapamycin modulates the immune system. I get that he's probably consulting a doctor but can you imagine taking this risk during a pandemic or even in older age? It makes me uncomfortable to play around with these very powerful drugs.
- jordanb 1y agoThese roads people go down always arrive at eating collidal silver...
- MarcelOlsz 1y agoGet with the times, methylene blue is the new it girl.
- malfist 1y agoAs a party trick, it'll make people pee blue. But don't do this, it isn't safe. Especially without consent
- YZF 1y agoThe dosage for longevity is supposed to be low enough that this risk is minimized. Lots of things you do modulate your immune system (including e.g. exercise). It's a risk/reward thing, every time you get into your car you're also taking a longevity risk. I think there are some proper human trials happening but the jury is still out.
- cactusplant7374 1y ago> I think there are some proper human trials happening but the jury is still out. That's exactly my point. No one really knows the risk that they are taking.
- rscho 1y agoSurprisingly, many people seem to think that pushing a few random pills into a machine optimized over some million years of evolution will tune it so it works better. Go figure...
- Etheryte 1y agoIt works for the majority of modern medicine, so it's not all that black and white.
- rscho 1y agoYes, although even for modern medicine curative and preventative strategies are very distinct. Sure, they'll give you pills to compensate for a problem you already have. But there are few meds that protect you against stuff you'll maybe catch in the future. Vaccines and antibiotics are obvious examples, but I'm not aware of many others. The rest of preventative strategies overwhelmingly consists in correcting deficits or excesses (calories, vitamins, sleep, exercise etc.)
- lokrian 1y agoPeople are still getting nerve damage from too much vitamin B6 in energy drinks and vitamin supplements, and that's a well known and widely taken vitamin. The idea that you can take experimental drugs your entire life at little risk is optimistic.
- rscho 1y agoHow to hedge a bet 101: 1.you bet on risky stuff using something of value (money, health,...) 2.since you're unsure whether your bet will pay off, you bet some more on some other risky stuff, just to be sure. BTW if you were wondering, of course all those proposed weird life-prolonging treatments are totally devoid of side-effects.
- malfist 1y agoOh there's plenty of people selling "side effect free" life extension supplements. But there's another name for side effect free medication: effect free.
- BobaFloutist 1y agoNever put 100% of your savings into a single slot machine. Take 10% of your savings to 10 different casinos and distribute them to 10 slot machines in each, in order to hedge.
- obloid 1y agoI recently saw a patient with overwhelming MRSA sepsis with multiple foci of infection including epidural abscess (around the spinal cord), and meningitis. This person was taking rapamycin presumably for "life extension" purposes. Almost certainly the immunosuppression from the rapamycin made the infection much worse. I'd be very wary of taking an immunosuppressive drug as an otherwise healthy person for theoretical life extension properties.
- loeg 1y agoAnd if diet alone isn't getting you to a healthy weight, the GLP-1 drugs are miraculously effective and don't have a lot of downsides aside from cost.
- FollowingTheDao 1y agoIs way too early to know about any downsides of these drugs. I’m afraid too many people are gonna find out the downsides when it’s too late.
- haar 1y agoI think for myself, regardless of what the downsides are - the likely alternative was death, which is still an option.
- malfist 1y agoThese drugs have been around since 2005. Exenatide was approved by the FDA for use in 2005. We've had plenty of time. Only their approval for weight loss is new
- FollowingTheDao 1y agoExenatide was a very small population base. The approval for weight loss means this drug is being taken by millions of more people which leads to a larger sample size. The larger the sample size the more negative effects will be revealed. I’ll just leave this here for the future m. I have no evidence other than common sense that it is ridiculous to think that injecting a hormone randomly in your body does not lead to side effects. Besides, who is going to be the one that links thyroid cancers and pancreatic cancers to these drugs? My father died of pancreatic cancer, no one really thought to ask why.
- daedrdev 1y agoThe majority is gaining literal years of healthy lifespan. It would take a lot of damage to even approach this gain for the average person. Like we used to do very invasive and impactful gastric surgery to try and get weight loss and nobody batted an eye, no?
- cm2012 1y agoYour overall mortality is actually best when you are overweight but not obese. Life expectancy at overweight bmi > standard bmi > obese bmi > underweight bmi. A few extra pounds when you are older helps you survive illness. The data is really really clear and replicated on this.
- derektank 1y agoThis only really holds for older people, who have basically no ability to recover lost muscle mass after a serious illness which makes it difficult them to continue to exercise.
- nahikoa 1y agoThe correlation is unambigous. The causation is a different story, e.g. illnesses often cause weight loss.
- standardUser 1y agoWhich segments of these populations have high BMI because of muscle mass instead of excess body fat? Which segments have low BMI due to childhood malnourishment or current or chronic illness? These are just some of the very obvious questions that have already been used to relegate your conveniently concise "fact" to "interesting, but not instructive".
- Aurornis 1y ago> A few extra pounds when you are older helps you survive illness. This doesn’t mean being slightly overweight from age 20 through 60 is an advantage.
- untrust 1y agoAnd sleep