3 ms·

I wonder if a similar technique could be used for Melatonin in saliva so that noninvasive circadian phase testing could be performed outside of the lab. I'm co

I wonder if a similar technique could be used for Melatonin in saliva so that noninvasive circadian phase testing could be performed outside of the lab. I'm convinced that if we actually looked at the circadian phase of the general population more closely we'd find A LOT of people with wonky clocks [1][2]. I've come to realize in recent months that I'm rocking a ~3h phase advance. Not terrible but it can sometimes make getting enough total sleep time challenging (bright light therapy in evenings really helps). 1. https://www.sydney.edu.au/news-opinion/news/2025/07/16/depression-linked-to-internal-jet-lag-study-finds.html https://www.sydney.edu.au/news-opinion/news/2025/07/16/depre... 2. Circadian Genes, Rhythms, and the Biology of Bipolar Disorder - https://www.youtube.com/watch?v=eSL5hC8bzcU https://www.youtube.com/watch?v=eSL5hC8bzcU

avidiax 1y ago
> I've come to realize in recent months that I'm rocking a ~3h phase advance. How did you figure that out? And having a phase advance should just mean that you could shift your bedtime and waking time forward but still get a similar amount of sleep compared to someone with a "neutral" phase, whatever that means.
- grumpy-de-sre 1y ago
  Shifting waking time forwards is straightforward but getting into bed early enough can be tough. As for the phase shift, I've always had what I thought was maintenance insomnia but at some point I realized I always waking at exactly 4:30am. Going to bed early resolves the maintenance insomnia (also travelling eastward more than a few hours or so). My father and brother are the same. I'd love to get a DLMO done to confirm. Thinking about experimenting with tracking core body temperature monitoring soon. FWIW a 24h ambulatory blood pressure study actually showed a phase advanced nocturnal dip.

3 ms·

I wonder if a similar technique could be used for Melatonin in saliva so that noninvasive circadian phase testing could be performed outside of the lab. I'm co

by grumpy-de-sre 1y ago

avidiax 1y ago
> I've come to realize in recent months that I'm rocking a ~3h phase advance. How did you figure that out? And having a phase advance should just mean that you could shift your bedtime and waking time forward but still get a similar amount of sleep compared to someone with a "neutral" phase, whatever that means.
- grumpy-de-sre 1y ago
  Shifting waking time forwards is straightforward but getting into bed early enough can be tough. As for the phase shift, I've always had what I thought was maintenance insomnia but at some point I realized I always waking at exactly 4:30am. Going to bed early resolves the maintenance insomnia (also travelling eastward more than a few hours or so). My father and brother are the same. I'd love to get a DLMO done to confirm. Thinking about experimenting with tracking core body temperature monitoring soon. FWIW a 24h ambulatory blood pressure study actually showed a phase advanced nocturnal dip.