Thiamine deficiency can cause anaerobic usage for example, without having to do intense exercise. Severe insulin resistance is another one. Cancer cells predomi

Thiamine deficiency can cause anaerobic usage for example, without having to do intense exercise. Severe insulin resistance is another one. Cancer cells predominantly use anaerobic burning (Warburg effect). Various blocks at mitochondrial level, such as carbon monoxide, can also drive metabolism towards anaerobic pathways.