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Given that recent Nature paper which claims that a lithium depletion could be responsible for Alzheimer's disease, is there any mechanism that could link increa
by hodgehog11 1y ago
Given that recent Nature paper which claims that a lithium depletion could be responsible for Alzheimer's disease, is there any mechanism that could link increased air pollution to a reduction in lithium levels?
- cluckindan 1y agoExposure to another similar metal could in theory displace lithium in biological processes.
- AnthonBerg 1y agoThe two have been posited: Lithium can be viewed an antioxidant – correctly or not?, I do not know. Air pollution can be viewed as oxidative stress. It’s interesting to search Google Scholar for “lithium antioxidant”.
- cyberax 1y agoLithium by itself is not an antioxidant. It's already oxidized in any bio-available compound, so it can't be used to reduce anything. But it apparently somehow modulates other systems that help with oxidative stress.
- AnthonBerg 1y agoThanks!
- ethan_smith 1y agoSome research suggests air pollution may disrupt blood-brain barrier integrity, potentially affecting mineral transport including lithium, while particulate matter can also bind to metal ions in the bloodstream altering their bioavailability.
- KolibriFly 1y agoRight now, most of the pollution–dementia work points more toward inflammation, oxidative stress, and vascular impacts rather than nutrient depletion