> Now, why the ion channels are the place to go Personal theory: these things are like "global constants" for the brain's GPU. Somewhat similar to the temperat

> Now, why the ion channels are the place to go Personal theory: these things are like "global constants" for the brain's GPU. Somewhat similar to the temperature constant in an LLM. There is no real "explanation" for why they work, they just have an effect. Various chemicals have various effects, often depending on the patient (because other constants vary, training data varies...) and we pick the chemical we like the effect of most.