I'm using mostly notebooks only (sometimes with an additional display) for some years. So I'm using no mouses, but trackpads or trackpoints. Never had problems

I'm using mostly notebooks only (sometimes with an additional display) for some years. So I'm using no mouses, but trackpads or trackpoints. Never had problems with my wrists. I think mouses are very nonergonomic devices. The increasing distribution of new input devices like touchscreens might change a lot, as hands are more in motion than with traditional devices.