4 ms·

True enough, but many studies show that calorie restriction reduces effects of aging

by leoh 1y ago

radu_floricica 1y ago
Not really applicable in humans. Effect is smaller than in mice, and requires some pretty drastic restrictions that aren't exactly pleasant. The thing with ozempic is that is seems to do several things, most (all?) of them good for us in different ways. We probably just lucked out. It's not the only case - plenty of drugs do incredibly good things with only reasonable side effects. Antibiotics. Ibuprofen. Aspirin. Vitamin D. A recent example - statins used to be seen as a tradeoff: you get better cardiovascular health, but some hepatotoxicity. Nope, it was wrong - they actually protect your liver. I think the official change came out this year, when I started them a couple of years ago I still found it framed as a side effect.
- simmerup 1y ago
  Statins change some peoples personalities https://www.bbc.co.uk/future/article/20200108-the-medications-that-change-who-we-are https://www.bbc.co.uk/future/article/20200108-the-medication...
  - radu_floricica 1y ago
    I don't think we really need to worry about rare and very rare side-effects. Or if we do, it'd be fair to also start worrying about all of them equally, but that would mean not taking any drugs ever.
    - esperent 1y ago
      > that would mean not taking any drugs ever. It would mean quantifying the risks of side effects versus the risks of not taking the drugs, which we should be doing anyway.
      - radu_floricica 1y ago
        Availability heuristic. If you read "changes in personality" listed as a very rare side effect on the drug's sheet (which yes, you should read once when you start taking the drug), you can evaluate it, maybe make a mental note etc. But if you make (or share) a bbc article on a particularly rare side effect, completely out of context, you're privileging the hypothesis. Why this particular side effects should be brought up for consideration? Other than in sounds weird and gets clicks.
- rscho 1y ago
  Ibuprofen ? That's really not something I'd have expected to end up in someone's 'healthy stuff' list. Ibuprofen increases the risk of cardiac event and is a common precipiting factor in renal failure. Most antibiotics also do not do only good things. The list is too long to write here. Side effects profiles change with research and marketing developments, but thinking these drugs are only beneficial is a bit over the top. Edit: I forgot. Ibuprofen also causes (non trivial) stomach bleeding and increases blood pressure. And many other things too.
  - selectodude 1y ago
    I’ll assume OP meant low-dose aspirin having cardioprotective effects.
    - rob74 1y ago
      Aspirin isn't the controversial item on OP's list, antibiotics and ibuprofen are.
  - JackFr 1y ago
    > Ibuprofen ? That's really not something I'd have expected to end up in someone's 'healthy stuff' list. Never knew about the potential stomach bleeds until I took my mother to the hospital earlier this year. Ironically, she was taking Motrin given to her in the same hospital a week earlier.
    - bloomingeek 1y ago
      Sorry to hear. My doc says to always eat something when taking ibuprofen to protect your stomach.
      - rscho 1y ago
        Yeah, something like omeprazole.
        1y ago
- rybosworld 1y ago
  Can you say more about Ibuprofen? I've understood it's fairly dangerous in some contexts. Especially for folks with compromised liver function.
  - amy214 1y ago
    tylenol is the one that's hepatotoxic (spanish for harmful to the liver) - ibuprofen is nephrotoxic (italian for harmful to the kidney) maybe you are mixing up your very similar painkillers. in kiddos it's common to go back and forth between them for pain control, thusly attenuating specific insult to liver or kidney. then there's aspirin, don't give that to kids, that's a whole thing
- ap99 1y ago
  Statins negatively affect mitochondria.
  - cthalupa 1y ago
    Not universally. Pitavastatin has a variety of beneficial effects on mitochondria and seems to have far more minimal impact on the CoQ10 pathway that some statins inhibit.
93po 1y ago
I've also seen info that i haven't verified that it seems to help with impulse control and executive functioning, so i imagine it would help reduce drug and alcohol consumption as well

True enough, but many studies show that calorie restriction reduces effects of aging

by leoh 1y ago

True enough, but many studies show that calorie restriction reduces effects of aging

Not really applicable in humans. Effect is smaller than in mice, and requires some pretty drastic restrictions that aren't exactly pleasant. The thing with ozempic is that is seems to do several things, most (all?) of them good for us in different ways. We probably just lucked out. It's not the only case - plenty of drugs do incredibly good things with only reasonable side effects. Antibiotics. Ibuprofen. Aspirin. Vitamin D. A recent example - statins used to be seen as a tradeoff: you get better cardiovascular health, but some hepatotoxicity. Nope, it was wrong - they actually protect your liver. I think the official change came out this year, when I started them a couple of years ago I still found it framed as a side effect.

simmerup 1y ago
Statins change some peoples personalities https://www.bbc.co.uk/future/article/20200108-the-medications-that-change-who-we-are https://www.bbc.co.uk/future/article/20200108-the-medication...
- radu_floricica 1y ago
  I don't think we really need to worry about rare and very rare side-effects. Or if we do, it'd be fair to also start worrying about all of them equally, but that would mean not taking any drugs ever.
  - esperent 1y ago
    > that would mean not taking any drugs ever. It would mean quantifying the risks of side effects versus the risks of not taking the drugs, which we should be doing anyway.
    - radu_floricica 1y ago
      Availability heuristic. If you read "changes in personality" listed as a very rare side effect on the drug's sheet (which yes, you should read once when you start taking the drug), you can evaluate it, maybe make a mental note etc. But if you make (or share) a bbc article on a particularly rare side effect, completely out of context, you're privileging the hypothesis. Why this particular side effects should be brought up for consideration? Other than in sounds weird and gets clicks.
rscho 1y ago
Ibuprofen ? That's really not something I'd have expected to end up in someone's 'healthy stuff' list. Ibuprofen increases the risk of cardiac event and is a common precipiting factor in renal failure. Most antibiotics also do not do only good things. The list is too long to write here. Side effects profiles change with research and marketing developments, but thinking these drugs are only beneficial is a bit over the top. Edit: I forgot. Ibuprofen also causes (non trivial) stomach bleeding and increases blood pressure. And many other things too.
- selectodude 1y ago
  I’ll assume OP meant low-dose aspirin having cardioprotective effects.
  - rob74 1y ago
    Aspirin isn't the controversial item on OP's list, antibiotics and ibuprofen are.
- JackFr 1y ago
  > Ibuprofen ? That's really not something I'd have expected to end up in someone's 'healthy stuff' list. Never knew about the potential stomach bleeds until I took my mother to the hospital earlier this year. Ironically, she was taking Motrin given to her in the same hospital a week earlier.
  - bloomingeek 1y ago
    Sorry to hear. My doc says to always eat something when taking ibuprofen to protect your stomach.
    - rscho 1y ago
      Yeah, something like omeprazole.
      - 1y ago
rybosworld 1y ago
Can you say more about Ibuprofen? I've understood it's fairly dangerous in some contexts. Especially for folks with compromised liver function.
- amy214 1y ago
  tylenol is the one that's hepatotoxic (spanish for harmful to the liver) - ibuprofen is nephrotoxic (italian for harmful to the kidney) maybe you are mixing up your very similar painkillers. in kiddos it's common to go back and forth between them for pain control, thusly attenuating specific insult to liver or kidney. then there's aspirin, don't give that to kids, that's a whole thing
ap99 1y ago
Statins negatively affect mitochondria.
- cthalupa 1y ago
  Not universally. Pitavastatin has a variety of beneficial effects on mitochondria and seems to have far more minimal impact on the CoQ10 pathway that some statins inhibit.

93po 1y ago

I've also seen info that i haven't verified that it seems to help with impulse control and executive functioning, so i imagine it would help reduce drug and alcohol consumption as well