3 ms·

This isn’t really surprising at all IMO, but it’s nice that it’s been confirmed. > “The researchers believe semaglutide’s anti-aging properties stem from its e

This isn’t really surprising at all IMO, but it’s nice that it’s been confirmed. > “The researchers believe semaglutide’s anti-aging properties stem from its effects on fat distribution and metabolic health. Excess fat around organs triggers the release of pro-aging molecules that alter DNA methylation in key aging-related genes. By reducing this harmful fat accumulation and preventing low-grade inflammation - both major drivers of epigenetic aging - semaglutide appears to create a more youthful biological environment.“ In other words, being medically obese ages your body quite a bit, its stresses out your body with inflammation, etc. Taking Ozempic helps people lose weight, which also reduces inflammation. This is sort of like saying we proved rain (usually) increases humidity lol. A very obvious finding. The article even says “ Randy Seeley from the University of Michigan Medical SchoolView company profile expressed little surprise at the findings” :)

torginus 1y ago
Yeah this is pretty much a nothingburger. I guess being fat causes biological damage similar to aging, and losing weight (which Ozempic helps with) reverses the process.
- ifwinterco 1y ago
  Yeah, it looks like it's basically just saying: 1) Being fat is really bad for you 2) Moderate calorie restriction may have some health benefits Both of which we already knew, the second one being a bit more controversial but a hypothesis that has been around for decades
  - ehnto 1y ago
    I think it's controversial mostly because it is mixed in with morality, self-image, personal freedom etc. I think everyone has the right to be fat, if they have chosen to prioritise other aspects of life, but I think people should be informed and consider the "being fat can be healthy" movement to be quite disingenuous. Do what you want, but be realistic about it, and tricking people into ignoring the negative effects is not fair to them either.
    - ifwinterco 1y ago
      Yeah it's clearly wrong, being fat is not healthy. There are multiple mechanistic explanations for why it might not be healthy (inflammation, hormones etc.), coupled with epidemiological evidence that obese people have massively higher rates of all sorts of health problems.
    - lurking_swe 1y ago
      is there a “being fat can be healthy” movement? I must be unaware. I am aware of the “fat people deserve respect, dignity, and can be beautiful too” movement…which i agree with. But if anyone is saying being fat is healthy, they’re pretending.
      - cthalupa 1y ago
        Yes, there are a variety of organizations that are attempting to propagate the idea that you can be healthy at any size. Which, as a formerly obese person, I knew was a load of bullshit even at my fattest. I don't know if anyone actually believes it, or if they just are lying to themselves, but the movement definitely exists.
      - ehnto 1y ago
        I also believe that everyone deserves respect and dignity, I don't even think it's amorale to choose to live life in a way that deprioritises health and fitness over other joys. I think maybe it's excessive to call it a movement, perhaps just a mindset that's propagated online. As the other commentor pointed out it's something I think companies can message poorly in their attempts to be inclusive.
Cpoll 1y ago
I've read [citation needed] that semaglutide has anti-inflammation effects even when there's no weight loss, i.e. there's another mechanism at play as well.

torginus 1y ago

Yeah this is pretty much a nothingburger. I guess being fat causes biological damage similar to aging, and losing weight (which Ozempic helps with) reverses the process.

ifwinterco 1y ago
Yeah, it looks like it's basically just saying: 1) Being fat is really bad for you 2) Moderate calorie restriction may have some health benefits Both of which we already knew, the second one being a bit more controversial but a hypothesis that has been around for decades
- ehnto 1y ago
  I think it's controversial mostly because it is mixed in with morality, self-image, personal freedom etc. I think everyone has the right to be fat, if they have chosen to prioritise other aspects of life, but I think people should be informed and consider the "being fat can be healthy" movement to be quite disingenuous. Do what you want, but be realistic about it, and tricking people into ignoring the negative effects is not fair to them either.
  - ifwinterco 1y ago
    Yeah it's clearly wrong, being fat is not healthy. There are multiple mechanistic explanations for why it might not be healthy (inflammation, hormones etc.), coupled with epidemiological evidence that obese people have massively higher rates of all sorts of health problems.
  - lurking_swe 1y ago
    is there a “being fat can be healthy” movement? I must be unaware. I am aware of the “fat people deserve respect, dignity, and can be beautiful too” movement…which i agree with. But if anyone is saying being fat is healthy, they’re pretending.
    - cthalupa 1y ago
      Yes, there are a variety of organizations that are attempting to propagate the idea that you can be healthy at any size. Which, as a formerly obese person, I knew was a load of bullshit even at my fattest. I don't know if anyone actually believes it, or if they just are lying to themselves, but the movement definitely exists.
    - ehnto 1y ago
      I also believe that everyone deserves respect and dignity, I don't even think it's amorale to choose to live life in a way that deprioritises health and fitness over other joys. I think maybe it's excessive to call it a movement, perhaps just a mindset that's propagated online. As the other commentor pointed out it's something I think companies can message poorly in their attempts to be inclusive.

Cpoll 1y ago

I've read [citation needed] that semaglutide has anti-inflammation effects even when there's no weight loss, i.e. there's another mechanism at play as well.