4 ms·
Kyoto University team develops pain reliever comparable to morphine
- petesergeant 1y agoMarginally more info, along with the title of the paper, but the doi is broken: https://medicalxpress.com/news/2025-08-discovery-analgesic-pain-relief-downsides.html https://medicalxpress.com/news/2025-08-discovery-analgesic-p... There's also the alternative Journavx: https://en.wikipedia.org/wiki/Suzetrigine https://en.wikipedia.org/wiki/Suzetrigine
- pogue 1y agoI can't find the study about this compound, Discovery and development of an oral analgesic targeting the α2B adrenoceptor, anywhere. I'd like to read more about the clinical pharmacology in detail.
- petesergeant 1y agoIf you didn't already find it, this has now shown up: https://www.pnas.org/doi/10.1073/pnas.2500006122 https://www.pnas.org/doi/10.1073/pnas.2500006122
- pogue 1y agoThank you!
- burnt-resistor 1y agoA new class of selective α2B-adrenoceptor antagonist.
- kelseyfrog 1y agoHow is it different from Imiloxan?
- erickhill 1y agoWhy is this written in such a way to only target cancer patients?
- bitwize 1y agoThe class of patients most likely to require opioids over long periods of time?
- delusional 1y agoAnd a class disproportionately insensitive to long term negative side effects.
- briangriffinfan 1y agoI have GOT to find a way to describe more things like this.
- lmm 1y agoProbably that's where the funding is available.
- raylad 1y agoIt works by causing a release of noadrenalin. Prediction: It will end up being used by the military and/or fighters to provide instantaneous muscle strength coupled with pain relief from overexertion.
- FirmwareBurner 1y agoStar Craft marine stim packs let's gooooo
- binary132 1y agoMy exact first thought
- harvie 1y agoIsn't that just gonna keep the patients in constant fight-or-flight mode? Perhaps developing PTSD or something over time...
- miningape 1y agoSounds like a secondary concern to me /s
- mvdtnz 1y agoIt's only constant if you constantly administer it
- buran77 1y agoWith soldiers it makes sense to use it explicitly to enforce the "fight" mode as needed. This can range from "occasionally in emergencies" to "all the time". But militaries have famously not cared about the long term health and well being of their forces past their active use. So any consequence of "long term fight mode" past victory day are just the cost of doing business.
- xeonmc 1y ago"Your injuries were not service related."
- cluckindan 1y agoSounds like it comes with an increased risk of stroke and cardiological issues, psychomotor agitation, anxiety, aggression, possibly even psychosis. Humans have noradrenaline regulation for a reason.
- elric 1y agoDoes the article not consider those to be serious side effects then? What is considered serious?
- cluckindan 1y agoIn this case, I believe ”serious side effects” is referring to opioid addiction and physical dependency.
- tsol 1y agoWe'll have to see. There are a lot of natural and experimental painkillers that aren't used either because of side effects or more often because they just don't work consistently. It just so happens that so far the opioids are the only ones that can handle extreme pain. It's a hard problem to solve
- tsoukase 1y agoIt is hard to beat morphine and its derivatives (eg fentanyl). In strict medical settings they are excellent analgetics and anxiolytics, safe with minor side effects. The only problem is when things go wary after the initial use (dependence etc).
- M95D 1y agoWhat about tolerance? Will it need increasing doses to be effective?