> It has now been shown to reduce malaria transmission by killing the mosquitoes that feed on treated individuals. That seems like it will interfere with carel

> It has now been shown to reduce malaria transmission by killing the mosquitoes that feed on treated individuals. That seems like it will interfere with careless randomized controlled trial design. If the drug kills mosquitos, it could easily do less well at preventing the user from getting infected by a mosquito, but it could potentially prevent an infected patient from spreading an infection via mosquito or even kill a mosquito that would otherwise subsequently spread an infection between two other people. In any case, here’s a better article. It seems the authors are very much aware of this issue, and they randomized entire clusters of people: https://www.science.org/content/article/well-known-drug-could-make-human-blood-toxic-malaria-transmitting-mosquitoes https://www.science.org/content/article/well-known-drug-coul...