That's missing the point altogether. A basic investigation will yield: * Memantine has NMDAr antagonism effects which will weaken depressive thoughts. * Meman

That's missing the point altogether. A basic investigation will yield: * Memantine has NMDAr antagonism effects which will weaken depressive thoughts. * Memantine has dopaminergic agonist activity (which builds very slowly), eventually improving mood. * Telmisartan has PPAR gamma activation effects which synergizes with its ARB effect for potent neurological benefits. * Intense exercise synergizes with all of the above, although it's less critical if the environmental trigger of depression is eliminated. A reductive investigation will find that the individual components don't cure depression, and that's beside the point. It is only their combination that fully normalizes things.