4 ms·
From the abstract: > Analysis of the TriNetX electronic health record database with data on 285 million patients revealed that the prevalence of chronic HCV wa
by _alternator_ 1y ago
From the abstract:
> Analysis of the TriNetX electronic health record database with data on 285 million patients revealed that the prevalence of chronic HCV was 3.6 and 3.9 percent in the SCZ and BPD populations respectively. The prevalence of chronic HCV in these populations was almost double that observed for MDD (1.8%) and approximately 7-fold higher than the control population (0.5%).
The association is real, but it’s not clear that HCV is a causal factor from this study. The only mechanistic bit that suggests a causal relation was that HCV indeed appeared in the brain (well, the choroid plexus) and may have triggered a local immune response. But the leap from that to “hepC causes schizophrenia and bipolar disorder” is pretty large.
- cwmoore 1y ago> “the leap from that to “hepC causes schizophrenia and bipolar disorder” is pretty large” Causally it’s the other way around? Obviously?
- _alternator_ 1y agoAt first blush, yes, would seem so. I’m not sure how well IV drug use was controlled for here; hopefully the experts can comment.