4 ms·
The bupropion (Wellbutrin) portion of the combination mentioned above serves as a CYP2D6 inhibitor as well, actually boosting the action of the DXM in the body.
by pharmacoguy 1y ago
The bupropion (Wellbutrin) portion of the combination mentioned above serves as a CYP2D6 inhibitor as well, actually boosting the action of the DXM in the body. Auvelity dosing starts lower with just 45mg of DXM, jumping to 90mg as the tolerance curve starts to set in.
- trehalose 1y agoCYP2D6 metabolizes DXM into a much more potent NMDA antagonist (dextrorphan, sometimes abbreviated to DXO). Inhibiting it boosts some action(s) of DXM but likely reduces the NMDA antagonist effect.