3 ms·

Memantine + half-dose telmisartan (for up to 3 months max) is remarkably effective for treating depression, with no addiction and no withdrawal. One does have t

Memantine + half-dose telmisartan (for up to 3 months max) is remarkably effective for treating depression, with no addiction and no withdrawal. One does have to scale up and scale down the doses gradually, and suffer the drowsiness and 10+ point BP reduction, but it works. Do not exceed 3 months because the dopaminergic effect of memantine will catch up by then, and you don't want psychosis from it. One must also avoid common triggers of depression, e.g. fast food, rancid oil, plastic packaging for hot foods, and air pollution from fires. It is also mandatory to engage in strenuous daily exercise, e.g. running, for this regimen to work, although exercise alone doesn't fix it. Of course, someone who hasn't tried it will find it easy to be critical and dismissive, but they're not the ones who need it, and their opinion doesn't matter. The beauty of this solution is that one you're treated, you're cured (assuming you stopped the environmental triggers). There are concrete logical pharmacological, neurological, and physiological reasons for this solution's effectiveness.

IAmGraydon 1y ago
So you posted a wall of medical advice - surely you have links to the peer reviewed studies that back it all up, right?
- hereme888 1y ago
  As inappropriate as it may seem, it's also inappropriate for any adult responsible for themselves to make their own health decisions per some random online comment, whether true or not.
  - OutOfHere 1y ago
    That's missing the point altogether. A basic investigation will yield: * Memantine has NMDAr antagonism effects which will weaken depressive thoughts. * Memantine has dopaminergic agonist activity (which builds very slowly), eventually improving mood. * Telmisartan has PPAR gamma activation effects which synergizes with its ARB effect for potent neurological benefits. * Intense exercise synergizes with all of the above, although it's less critical if the environmental trigger of depression is eliminated. A reductive investigation will find that the individual components don't cure depression, and that's beside the point. It is only their combination that fully normalizes things.
    - hereme888 1y ago
      "It is only their combination that fully normalizes things." Is that a theory based on your basic investigation, or is there a clinical trial showing the theory works in real life?

IAmGraydon 1y ago

So you posted a wall of medical advice - surely you have links to the peer reviewed studies that back it all up, right?

hereme888 1y ago
As inappropriate as it may seem, it's also inappropriate for any adult responsible for themselves to make their own health decisions per some random online comment, whether true or not.
- OutOfHere 1y ago
  That's missing the point altogether. A basic investigation will yield: * Memantine has NMDAr antagonism effects which will weaken depressive thoughts. * Memantine has dopaminergic agonist activity (which builds very slowly), eventually improving mood. * Telmisartan has PPAR gamma activation effects which synergizes with its ARB effect for potent neurological benefits. * Intense exercise synergizes with all of the above, although it's less critical if the environmental trigger of depression is eliminated. A reductive investigation will find that the individual components don't cure depression, and that's beside the point. It is only their combination that fully normalizes things.
  - hereme888 1y ago
    "It is only their combination that fully normalizes things." Is that a theory based on your basic investigation, or is there a clinical trial showing the theory works in real life?