3 ms·
This article is remarkable incomplete. Why is he only talking about the effect ion the NMDA receptor when ketamine effect much more than that and a lot of stuff
by FollowingTheDao 1y ago
This article is remarkable incomplete. Why is he only talking about the effect ion the NMDA receptor when ketamine effect much more than that and a lot of stuff we do not know. At higher doses it start effecting other receptors which is why a higher does has seemingly opposite effects.
You can see the K values for the receptors ketamine effects on wikipedia:
https://en.wikipedia.org/wiki/Ketamine#Pharmacology https://en.wikipedia.org/wiki/Ketamine#Pharmacology
He does not seem to know ketamine is a D2 receptor agonsit, the same as PCP, yet he mentions it for PCP!
Like most of the "nootropics" people I read they speak only in "vibes".
- grillbert 1y agoAuthor here, >This article is remarkable incomplete True! There's other posts in this vein on the blog. Most recent posts have concerned the NMDA Receptor, i'm mainly using ketamine to tease out intracellular effects of different NMDAR currents. >At higher doses it start effecting other receptors which is why a higher does has seemingly opposite effects. Also true, but not sure if that necessarily conflicts with what I'm writing about here in comparing Ketamine to Memantine. >He does not seem to know ketamine is a D2 receptor agonsit, the same as PCP, yet he mentions it for PCP! Learned this halfway through writing, forgot to amend that section. Completely on me.