3 ms·

So, what products would work as "sleep in a pill", at least on the "not being exhausted" part (I suppose the "not getting crazy because of lack of REM sleep" wo

So, what products would work as "sleep in a pill", at least on the "not being exhausted" part (I suppose the "not getting crazy because of lack of REM sleep" would be different) ?

A_D_E_P_T 1y ago
Speculative: Gentle mitochondrial uncouplers that cross the BBB very well, possibly in conjunction with elamipretide, MitoQ, MitoTEMPO, or something similar.
- kridsdale1 1y ago
  Would these also have a thermogenesis effect? I used that hyper deadly illegal one (can’t remember the name, very yellow) several years ago and got a sauna in my torso (shredded abs too) but didn’t notice any perceptual energy balance change.
  - A_D_E_P_T 1y ago
    Yeah, probably. DNP (2,4-Dinitrophenol) is the stuff you took. It's reported to cross the BBB, but it's so toxic, with such a narrow therapeutic window, that most people report feeling pretty sick on it.
storus 1y ago
I would look at PQQ, CoQ10, B-complex, GlyNAC or just glycine, AXA1125, R ALA, DCA, creatine; those are known to improve mitochondrial fitness under various mechanisms. Add 99%-100% dark chocolate and exercise, both of which act similarly to PQQ. Theanine for increasing GABA, primary calming neurotransmitter.
- kridsdale1 1y ago
  I back this up as a human who is doing 90% of these and has a daily A/B test of perceived energy balance and endurance difference depending on using them. Thank you for the tip about DCA!
robwwilliams 1y ago
There will not be “sleep in a pill”. Even the happiest of mitochondria and cells have been entrained for eons to circadian rhythms. (Even benthic deep sea fish sleep; well cyclic rest behavior.) Long-distance drivers and pilots on long missions have their drugs of choice (e.g., Modafinil), but they are crutches, not replacements. There is good evidence that fur seals, rays, and some sharks have brain asymmetry in sleep, with half the brain sleeping while the other half keeps an eye open. Unihemispheric sleep! Convenient. https://www.science.org/doi/10.1126/science.adf0566 https://www.science.org/doi/10.1126/science.adf0566
HarHarVeryFunny 1y ago
If you want to pull an all-nighter then caffeine pills will keep you awake and alert, but no substitute for sleep. I'm sure if you did this for multiple days in a row, you'd be just as messed up as if you forced yourself to stay awake without the pills.

So, what products would work as "sleep in a pill", at least on the "not being exhausted" part (I suppose the "not getting crazy because of lack of REM sleep" would be different) ?

A_D_E_P_T 1y ago

Speculative: Gentle mitochondrial uncouplers that cross the BBB very well, possibly in conjunction with elamipretide, MitoQ, MitoTEMPO, or something similar.

kridsdale1 1y ago
Would these also have a thermogenesis effect? I used that hyper deadly illegal one (can’t remember the name, very yellow) several years ago and got a sauna in my torso (shredded abs too) but didn’t notice any perceptual energy balance change.
- A_D_E_P_T 1y ago
  Yeah, probably. DNP (2,4-Dinitrophenol) is the stuff you took. It's reported to cross the BBB, but it's so toxic, with such a narrow therapeutic window, that most people report feeling pretty sick on it.

storus 1y ago

I would look at PQQ, CoQ10, B-complex, GlyNAC or just glycine, AXA1125, R ALA, DCA, creatine; those are known to improve mitochondrial fitness under various mechanisms. Add 99%-100% dark chocolate and exercise, both of which act similarly to PQQ. Theanine for increasing GABA, primary calming neurotransmitter.

kridsdale1 1y ago
I back this up as a human who is doing 90% of these and has a daily A/B test of perceived energy balance and endurance difference depending on using them. Thank you for the tip about DCA!

robwwilliams 1y ago

There will not be “sleep in a pill”. Even the happiest of mitochondria and cells have been entrained for eons to circadian rhythms. (Even benthic deep sea fish sleep; well cyclic rest behavior.) Long-distance drivers and pilots on long missions have their drugs of choice (e.g., Modafinil), but they are crutches, not replacements. There is good evidence that fur seals, rays, and some sharks have brain asymmetry in sleep, with half the brain sleeping while the other half keeps an eye open. Unihemispheric sleep! Convenient. https://www.science.org/doi/10.1126/science.adf0566 https://www.science.org/doi/10.1126/science.adf0566

HarHarVeryFunny 1y ago

If you want to pull an all-nighter then caffeine pills will keep you awake and alert, but no substitute for sleep. I'm sure if you did this for multiple days in a row, you'd be just as messed up as if you forced yourself to stay awake without the pills.